Search Results

Overview

Uniprot IDQ8WTT2
Protein NameNucleolar complex protein 3 homolog
Gene NameNOC3L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
123 SSEPVHAKKRKHERI
133 KHERIIDKYEKIPRT
136 RIIDKYEKIPRTLQT
156 LIHLLPIKDKSGIIP
158 HLLPIKDKSGIIPQT
326 WKQRKLKKSNVVSLK

Function

May be required for adipogenesis

Protein Sequence

10 MKARRNKKQI 20 PSFRKLIKTS 30 KVKLENKLKN 40 KQFKQQSTLK 50 KYRKEQRKLR 60 QAVKDAVSKK 70 PIPLENPKEK 80 RPGKRIEREE 90 EEEEEALPLD 100 MMDEDDLQLM 110 KDLGQRVSFL 120 TRDLSSSEPV 130 HAKKRKHERI 140 IDKYEKIPRT 150 LQTAPEKELI 160 HLLPIKDKSG 170 IIPQTREKPV 180 TDSNKDEEDQ 190 EEERELEEEI 200 IEDPIQELTI 210 EEHLIERKKK 220 LQEKKMHIAA 230 LASAILSDPE 240 NNIKKLKELR 250 SMLMEQDPDV 260 AVTVRKLVIV 270 SLMELFKDIT 280 PSYKIRPLTE 290 AEKSTKTRKE 300 TQKLREFEEG 310 LVSQYKFYLE 320 NLEQMVKDWK 330 QRKLKKSNVV 340 SLKAYKGLAE 350 VAVKSLCELL 360 VALPHFNFHN 370 NIIVLIVPLM 380 NDMSKLISEM 390 CCEAVKKLFK 400 QDKLGQASLG 410 VIKVISGFVK 420 GRNYEVRPEM 430 LKTFLCLRIK 440 EVEVKKDTED 450 INKPKKFMTF 460 KEKRKSLSRM 470 QRKWKKAEEK 480 LERELREAEA 490 SESTEKKLKL 500 HTETLNIVFV 510 TYFRILKKAQ 520 RSPLLPAVLE 530 GLAKFAHLIN 540 VEFFDDLLVV 550 LHTLIESGDL 560 SYQESLHCVQ 570 TAFHILSGQG 580 DVLNIDPLKF 590 YTHLYKTLFK 600 LHAGATNEGV 610 EIVLQCLDVM 620 LTKRRKQVSQ 630 QRALAFIKRL 640 CTLALHVLPN 650 SSIGILATTR 660 ILMHTFPKTD 670 LLLDSESQGS 680 GVFLPELDEP 690 EYCNAQNTAL 700 WELHALRRHY 710 HPIVQRFAAH 720 LIAGAPSEGS 730 GALKPELSRR 740 SATELFEAYS 750 MAEMTFNPPV 760 ESSNPKIKGK 770 FLQGDSFLNE 780 DLNQLIKRYS 790 SEVATESPLD 800 FTKYLKTSLH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006270 DNA replication initiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.