Search Results

Overview

Uniprot IDQ8WTW3
Protein NameConserved oligomeric Golgi complex subunit 1
Gene NameCOG1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
656 LRKQGKVKTQEIIPT

Function

Required for normal Golgi function

Protein Sequence

10 MATAATSPAL 20 KRLDLRDPAA 30 LFETHGAEEI 40 RGLERQVRAE 50 IEHKKEELRQ 60 MVGERYRDLI 70 EAADTIGQMR 80 RCAVGLVDAV 90 KATDQYCARL 100 RQAGSAAPRP 110 PRAQQPQQPS 120 QEKFYSMAAQ 130 IKLLLEIPEK 140 IWSSMEASQC 150 LHATQLYLLC 160 CHLHSLLQLD 170 SSSSRYSPVL 180 SRFPILIRQV 190 AAASHFRSTI 200 LHESKMLLKC 210 QGVSDQAVAE 220 ALCSIMLLEE 230 SSPRQALTDF 240 LLARKATIQK 250 LLNQPHHGAG 260 IKAQICSLVE 270 LLATTLKQAH 280 ALFYTLPEGL 290 LPDPALPCGL 300 LFSTLETITG 310 QHPAGKGTGV 320 LQEEMKLCSW 330 FKHLPASIVE 340 FQPTLRTLAH 350 PISQEYLKDT 360 LQKWIHMCNE 370 DIKNGITNLL 380 MYVKSMKGLA 390 GIRDAMWELL 400 TNESTNHSWD 410 VLCRRLLEKP 420 LLFWEDMMQQ 430 LFLDRLQTLT 440 KEGFDSISSS 450 SKELLVSALQ 460 ELESSTSNSP 470 SNKHIHFEYN 480 MSLFLWSESP 490 NDLPSDAAWV 500 SVANRGQFAS 510 SGLSMKAQAI 520 SPCVQNFCSA 530 LDSKLKVKLD 540 DLLAYLPSDD 550 SSLPKDVSPT 560 QAKSSAFDRY 570 ADAGTVQEML 580 RTQSVACIKH 590 IVDCIRAELQ 600 SIEEGVQGQQ 610 DALNSAKLHS 620 VLFMARLCQS 630 LGELCPHLKQ 640 CILGKSESSE 650 KPAREFRALR 660 KQGKVKTQEI 670 IPTQAKWQEV 680 KEVLLQQSVM 690 GYQVWSSAVV 700 KVLIHGFTQS 710 LLLDDAGSVL 720 ATATSWDELE 730 IQEEAESGSS 740 VTSKIRLPAQ 750 PSWYVQSFLF 760 SLCQEINRVG 770 GHALPKVTLQ 780 EMLKSCMVQV 790 VAAYEKLSEE 800 KQIKKEGAFP 810 VTQNRALQLL 820 YDLRYLNIVL 830 TAKGDEVKSG 840 RSKPDSRIEK 850 VTDHLEALID 860 PFDLDVFTPH 870 LNSNLHRLVQ 880 RTSVLFGLVT 890 GTENQLAPRS 900 STFNSQEPHN 910 ILPLASSQIR 920 FGLLPLSMTS 930 TRKAKSTRNI 940 ETKAQVVPPA 950 RSTAGDPTVP 960 GSLFRQLVSE 970 EDNTSAPSLF 980 KLGWLSSMTK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0017119 Golgi transport complex
Cellular Component GO:0032588 trans-Golgi network membrane
Biological Process GO:0007030 Golgi organization
Biological Process GO:0006891 intra-Golgi vesicle-mediated transport
Biological Process GO:0015031 protein transport
Biological Process GO:0000301 retrograde transport, vesicle recycling within Golgi

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.