Search Results

Overview

Uniprot IDQ8WU90
Protein NameZinc finger CCCH domain-containing protein 15
Gene NameZC3H15
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
22 AEQKKKEKIIEDKTF
27 KEKIIEDKTFGLKNK
285 KADFKAGKALVISGR
32 EDKTFGLKNKKGAKQ
34 KTFGLKNKKGAKQQK
41 KKGAKQQKFIKAVTH
44 AKQQKFIKAVTHQVK
51 KAVTHQVKFGQQNPR
93 KPVVAAQKISKGADP

Function

Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155)

Protein Sequence

10 MPPKKQAQAG 20 GSKKAEQKKK 30 EKIIEDKTFG 40 LKNKKGAKQQ 50 KFIKAVTHQV 60 KFGQQNPRQV 70 AQSEAEKKLK 80 KDDKKKELQE 90 LNELFKPVVA 100 AQKISKGADP 110 KSVVCAFFKQ 120 GQCTKGDKCK 130 FSHDLTLERK 140 CEKRSVYIDA 150 RDEELEKDTM 160 DNWDEKKLEE 170 VVNKKHGEAE 180 KKKPKTQIVC 190 KHFLEAIENN 200 KYGWFWVCPG 210 GGDICMYRHA 220 LPPGFVLKKD 230 KKKEEKEDEI 240 SLEDLIERER 250 SALGPNVTKI 260 TLESFLAWKK 270 RKRQEKIDKL 280 EQDMERRKAD 290 FKAGKALVIS 300 GREVFEFRPE 310 LVNDDDEEAD 320 DTRYTQGTGG 330 DEVDDSVSVN 340 DIDLSLYIPR 350 DVDETGITVA 360 SLERFSTYTS 370 DKDENKLSEA 380 SGGRAENGER 390 SDLEEDNERE 400 GTENGAIDAV 410 PVDENLFTGE 420 DLDELEEELN TLDLEE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0002181 cytoplasmic translation
Biological Process GO:0043547 positive regulation of GTPase activity

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.