Search Results

Overview

Uniprot ID	Q8WUA2
Protein Name	Peptidyl-prolyl cis-trans isomerase-like 4
Gene Name	PPIL4
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
333	GKGGKYTKSDFKEYE
352	KPPNLVLKDKVKPKQ
362	VKPKQDTKYDLILDE
375	DEQAEDSKSSHSHTS
383	SSHSHTSKKHKKKTH
384	SHSHTSKKHKKKTHH
388	TSKKHKKKTHHCSEE
405	DEDYMPIKNTNQDIY
460	YSNSHKSKYQTDLYE

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)

Protein Sequence

10 MAVLLETTLG 20 DVVIDLYTEE 30 RPRACLNFLK 40 LCKIKYYNYC 50 LIHNVQRDFI 60 IQTGDPTGTG 70 RGGESIFGQL 80 YGDQASFFEA 90 EKVPRIKHKK 100 KGTVSMVNNG 110 SDQHGSQFLI 120 TTGENLDYLD 130 GVHTVFGEVT 140 EGMDIIKKIN 150 ETFVDKDFVP 160 YQDIRINHTV 170 ILDDPFDDPP 180 DLLIPDRSPE 190 PTREQLDSGR 200 IGADEEIDDF 210 KGRSAEEVEE 220 IKAEKEAKTQ 230 AILLEMVGDL 240 PDADIKPPEN 250 VLFVCKLNPV 260 TTDEDLEIIF 270 SRFGPIRSCE 280 VIRDWKTGES 290 LCYAFIEFEK 300 EEDCEKAFFK 310 MDNVLIDDRR 320 IHVDFSQSVA 330 KVKWKGKGGK 340 YTKSDFKEYE 350 KEQDKPPNLV 360 LKDKVKPKQD 370 TKYDLILDEQ 380 AEDSKSSHSH 390 TSKKHKKKTH 400 HCSEEKEDED 410 YMPIKNTNQD 420 IYREMGFGHY 430 EEEESCWEKQ 440 KSEKRDRTQN 450 RSRSRSRERD 460 GHYSNSHKSK 470 YQTDLYERER 480 SKKRDRSRSP 490 KKSKDKEKSK YR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0000398	mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.