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Overview

Uniprot IDQ8WUA4
Protein NameGeneral transcription factor 3C polypeptide 2
Gene NameGTF3C2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
148 KKRGRKSKAELLLLK
155 KAELLLLKLSKDLDR
158 LLLLKLSKDLDRPES
90 DLSSEMSKVSKPRAS

Function

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1

Protein Sequence

10 MDTCGVGYVA 20 LGEAGPVGNM 30 TVVDSPGQEV 40 LNQLDVKTSS 50 EMTSAEASVE 60 MSLPTPLPGF 70 EDSPDQRRLP 80 PEQESLSRLE 90 QPDLSSEMSK 100 VSKPRASKPG 110 RKRGGRTRKG 120 PKRPQQPNPP 130 SAPLVPGLLD 140 QSNPLSTPMP 150 KKRGRKSKAE 160 LLLLKLSKDL 170 DRPESQSPKR 180 PPEDFETPSG 190 ERPRRRAAQV 200 ALLYLQELAE 210 ELSTALPAPV 220 SCPEGPKVSS 230 PTKPKKIRQP 240 AACPGGEEVD 250 GAPRDEDFFL 260 QVEAEDVEES 270 EGPSESSSEP 280 EPVVPRSTPR 290 GSTSGKQKPH 300 CRGMAPNGLP 310 NHIMAPVWKC 320 LHLTKDFREQ 330 KHSYWEFAEW 340 IPLAWKWHLL 350 SELEAAPYLP 360 QEEKSPLFSV 370 QREGLPEDGT 380 LYRINRFSSI 390 TAHPERWDVS 400 FFTGGPLWAL 410 DWCPVPEGAG 420 ASQYVALFSS 430 PDMNETHPLS 440 QLHSGPGLLQ 450 LWGLGTLQQE 460 SCPGNRAHFV 470 YGIACDNGCI 480 WDLKFCPSGA 490 WELPGTPRKA 500 PLLPRLGLLA 510 LACSDGKVLL 520 FSLPHPEALL 530 AQQPPDAVKP 540 AIYKVQCVAT 550 LQVGSMQATD 560 PSECGQCLSL 570 AWMPTRPHQH 580 LAAGYYNGMV 590 VFWNLPTNSP 600 LQRIRLSDGS 610 LKLYPFQCFL 620 AHDQAVRTLQ 630 WCKANSHFLV 640 SAGSDRKIKF 650 WDLRRPYEPI 660 NSIKRFLSTE 670 LAWLLPYNGV 680 TVAQDNCYAS 690 YGLCGIHYID 700 AGYLGFKAYF 710 TAPRKGTVWS 720 LSGSDWLGTI 730 AAGDISGELI 740 AAILPDMALN 750 PINVKRPVER 760 RFPIYKADLI 770 PYQDSPEGPD 780 HSSASSGVPN 790 PPKARTYTET 800 VNHHYLLFQD 810 TDLGSFHDLL 820 RREPMLRMQE 830 GEGHSQLCLD 840 RLQLEAIHKV 850 RFSPNLDSYG 860 WLVSGGQSGL 870 VRIHFVRGLA 880 SPLGHRMQLE 890 SRAHFNAMFQ 900 PSSPTRRPGF 910 SPTSHRLLPT P

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000127 transcription factor TFIIIC complex
Molecular Function GO:0000995 RNA polymerase III general transcription initiation factor activity
Biological Process GO:0042791 5S class rRNA transcription by RNA polymerase III
Biological Process GO:0006383 transcription by RNA polymerase III
Biological Process GO:0006384 transcription initiation at RNA polymerase III promoter
Biological Process GO:0042797 tRNA transcription by RNA polymerase III

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.