Search Results

Overview

Uniprot IDQ8WUF5
Protein NameRelA-associated inhibitor
Gene NamePPP1R13L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
115 PYSPLSPKGRPSSPR
248 TLRRRPPKAWNESDL
314 ATLPRNYKVSPLASD
87 GSRGSPRKAATDGAD

Function

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640)

Protein Sequence

10 MDSEAFQSAR 20 DFLDMNFQSL 30 AMKHMDLKQM 40 ELDTAAAKVD 50 ELTKQLESLW 60 SDSPAPPGPQ 70 AGPPSRPPRY 80 SSSSIPEPFG 90 SRGSPRKAAT 100 DGADTPFGRS 110 ESAPTLHPYS 120 PLSPKGRPSS 130 PRTPLYLQPD 140 AYGSLDRATS 150 PRPRAFDGAG 160 SSLGRAPSPR 170 PGPGPLRQQG 180 PPTPFDFLGR 190 AGSPRGSPLA 200 EGPQAFFPER 210 GPSPRPPATA 220 YDAPASAFGS 230 SLLGSGGSAF 240 APPLRAQDDL 250 TLRRRPPKAW 260 NESDLDVAYE 270 KKPSQTASYE 280 RLDVFARPAS 290 PSLQLLPWRE 300 SSLDGLGGTG 310 KDNLTSATLP 320 RNYKVSPLAS 330 DRRSDAGSYR 340 RSLGSAGPSG 350 TLPRSWQPVS 360 RIPMPPSSPQ 370 PRGAPRQRPI 380 PLSMIFKLQN 390 AFWEHGASRA 400 MLPGSPLFTR 410 APPPKLQPQP 420 QPQPQPQSQP 430 QPQLPPQPQT 440 QPQTPTPAPQ 450 HPQQTWPPVN 460 EGPPKPPTEL 470 EPEPEIEGLL 480 TPVLEAGDVD 490 EGPVARPLSP 500 TRLQPALPPE 510 AQSVPELEEV 520 ARVLAEIPRP 530 LKRRGSMEQA 540 PAVALPPTHK 550 KQYQQIISRL 560 FHRHGGPGPG 570 GPEPELSPIT 580 EGSEARAGPP 590 APAPPAPIPP 600 PAPSQSSPPE 610 QPQSMEMRSV 620 LRKAGSPRKA 630 RRARLNPLVL 640 LLDAALTGEL 650 EVVQQAVKEM 660 NDPSQPNEEG 670 ITALHNAICG 680 ANYSIVDFLI 690 TAGANVNSPD 700 SHGWTPLHCA 710 ASCNDTVICM 720 ALVQHGAAIF 730 ATTLSDGATA 740 FEKCDPYREG 750 YADCATYLAD 760 VEQSMGLMNS 770 GAVYALWDYS 780 AEFGDELSFR 790 EGESVTVLRR 800 DGPEETDWWW 810 AALHGQEGYV 820 PRNYFGLFPR VKPQRSKV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0045597 positive regulation of cell differentiation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.