Search Results

Overview

Uniprot IDQ8WUM0
Protein NameNuclear pore complex protein Nup133
Gene NameNUP133
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
135 IALSPITKLSVCKEL
35 TPRTASRKGLPLGSA

Function

Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222)

Protein Sequence

10 MFPAAPSPRT 20 PGTGSRRGPL 30 AGLGPGSTPR 40 TASRKGLPLG 50 SAVSSPVLFS 60 PVGRRSSLSS 70 RGTPTRMFPH 80 HSITESVNYD 90 VKTFGSSLPV 100 KVMEALTLAE 110 VDDQLTINID 120 EGGWACLVCK 130 EKLIIWKIAL 140 SPITKLSVCK 150 ELQLPPSDFH 160 WSADLVALSY 170 SSPSGEAHST 180 QAVAVMVATR 190 EGSIRYWPSL 200 AGEDTYTEAF 210 VDSGGDKTYS 220 FLTAVQGGSF 230 ILSSSGSQLI 240 RLIPESSGKI 250 HQHILPQGQG 260 MLSGIGRKVS 270 SLFGILSPSS 280 DLTLSSVLWD 290 RERSSFYSLT 300 SSNISKWELD 310 DSSEKHAYSW 320 DINRALKENI 330 TDAIWGSESN 340 YEAIKEGVNI 350 RYLDLKQNCD 360 GLVILAAAWH 370 SADNPCLIYY 380 SLITIEDNGC 390 QMSDAVTVEV 400 TQYNPPFQSE 410 DLILCQLTVP 420 NFSNQTAYLY 430 NESAVYVCST 440 GTGKFSLPQE 450 KIVFNAQGDS 460 VLGAGACGGV 470 PIIFSRNSGL 480 VSITSRENVS 490 ILAEDLEGSL 500 ASSVAGPNSE 510 SMIFETTTKN 520 ETIAQEDKIK 530 LLKAAFLQYC 540 RKDLGHAQMV 550 VDELFSSHSD 560 LDSDSELDRA 570 VTQISVDLMD 580 DYPASDPRWA 590 ESVPEEAPGF 600 SNTSLIILHQ 610 LEDKMKAHSF 620 LMDFIHQVGL 630 FGRLGSFPVR 640 GTPMATRLLL 650 CEHAEKLSAA 660 IVLKNHHSRL 670 SDLVNTAILI 680 ALNKREYEIP 690 SNLTPADVFF 700 REVSQVDTIC 710 ECLLEHEEQV 720 LRDAPMDSIE 730 WAEVVINVNN 740 ILKDMLQAAS 750 HYRQNRNSLY 760 RREESLEKEP 770 EYVPWTATSG 780 PGGIRTVIIR 790 QHEIVLKVAY 800 PQADSNLRNI 810 VTEQLVALID 820 CFLDGYVSQL 830 KSVDKSSNRE 840 RYDNLEMEYL 850 QKRSDLLSPL 860 LSLGQYLWAA 870 SLAEKYCDFD 880 ILVQMCEQTD 890 NQSRLQRYMT 900 QFADQNFSDF 910 LFRWYLEKGK 920 RGKLLSQPIS 930 QHGQLANFLQ 940 AHEHLSWLHE 950 INSQELEKAH 960 ATLLGLANME 970 TRYFAKKKTL 980 LGLSKLAALA 990 SDFSEDMLQE 1000 KIEEMAEQER 1010 FLLHQETLPE 1020 QLLAEKQLNL 1030 SAMPVLTAPQ 1040 LIGLYICEEN 1050 RRANEYDFKK 1060 ALDLLEYIDE 1070 EEDININDLK 1080 LEILCKALQR 1090 DNWSSSDGKD 1100 DPIEVSKDSI 1110 FVKILQKLLK 1120 DGIQLSEYLP 1130 EVKDLLQADQ 1140 LGSLKSNPYF 1150 EFVLKANYEY YVQGQI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0016020 membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0031080 nuclear pore outer ring
Molecular Function GO:0017056 structural constituent of nuclear pore
Biological Process GO:0006406 mRNA export from nucleus
Biological Process GO:0072006 nephron development
Biological Process GO:0006999 nuclear pore organization
Biological Process GO:0006913 nucleocytoplasmic transport
Biological Process GO:0016973 poly(A)+ mRNA export from nucleus
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.