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Overview

Uniprot IDQ8WUM4
Protein NameProgrammed cell death 6-interacting protein
Gene NamePDCD6IP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
234 AFKQCQYKDTLPKEV
285 QHAAELIKTVASRYD
312 NRALAAAKKDNDFIY
374 LAAYNQRKADLVNRS
486 TPSNELYKPLRAEGT
614 VYGGLTTKVQESLKK

Function

Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity)

Protein Sequence

10 MATFISVQLK 20 KTSEVDLAKP 30 LVKFIQQTYP 40 SGGEEQAQYC 50 RAAEELSKLR 60 RAAVGRPLDK 70 HEGALETLLR 80 YYDQICSIEP 90 KFPFSENQIC 100 LTFTWKDAFD 110 KGSLFGGSVK 120 LALASLGYEK 130 SCVLFNCAAL 140 ASQIAAEQNL 150 DNDEGLKIAA 160 KHYQFASGAF 170 LHIKETVLSA 180 LSREPTVDIS 190 PDTVGTLSLI 200 MLAQAQEVFF 210 LKATRDKMKD 220 AIIAKLANQA 230 ADYFGDAFKQ 240 CQYKDTLPKE 250 VFPVLAAKHC 260 IMQANAEYHQ 270 SILAKQQKKF 280 GEEIARLQHA 290 AELIKTVASR 300 YDEYVNVKDF 310 SDKINRALAA 320 AKKDNDFIYH 330 DRVPDLKDLD 340 PIGKATLVKS 350 TPVNVPISQK 360 FTDLFEKMVP 370 VSVQQSLAAY 380 NQRKADLVNR 390 SIAQMREATT 400 LANGVLASLN 410 LPAAIEDVSG 420 DTVPQSILTK 430 SRSVIEQGGI 440 QTVDQLIKEL 450 PELLQRNREI 460 LDESLRLLDE 470 EEATDNDLRA 480 KFKERWQRTP 490 SNELYKPLRA 500 EGTNFRTVLD 510 KAVQADGQVK 520 ECYQSHRDTI 530 VLLCKPEPEL 540 NAAIPSANPA 550 KTMQGSEVVN 560 VLKSLLSNLD 570 EVKKEREGLE 580 NDLKSVNFDM 590 TSKFLTALAQ 600 DGVINEEALS 610 VTELDRVYGG 620 LTTKVQESLK 630 KQEGLLKNIQ 640 VSHQEFSKMK 650 QSNNEANLRE 660 EVLKNLATAY 670 DNFVELVANL 680 KEGTKFYNEL 690 TEILVRFQNK 700 CSDIVFARKT 710 ERDELLKDLQ 720 QSIAREPSAP 730 SIPTPAYQSS 740 PAGGHAPTPP 750 TPAPRTMPPT 760 KPQPPARPPP 770 PVLPANRAPS 780 ATAPSPVGAG 790 TAAPAPSQTP 800 GSAPPPQAQG 810 PPYPTYPGYP 820 GYCQMPMPMG 830 YNPYAYGQYN 840 MPYPPVYHQS 850 PGQAPYPGPQ 860 QPSYPFPQPP QQSYYPQQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042641 actomyosin
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070971 endoplasmic reticulum exit site
Cellular Component GO:0005768 endosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0090543 Flemming body
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0001772 immunological synapse
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Molecular Function GO:0048306 calcium-dependent protein binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0031871 proteinase activated receptor binding
Biological Process GO:0000915 actomyosin contractile ring assembly
Biological Process GO:0006915 apoptotic process
Biological Process GO:0070830 bicellular tight junction assembly
Biological Process GO:0097734 extracellular exosome biogenesis
Biological Process GO:0016236 macroautophagy
Biological Process GO:0045199 maintenance of epithelial cell apical/basal polarity
Biological Process GO:0061952 midbody abscission
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0036258 multivesicular body assembly
Biological Process GO:1903543 positive regulation of exosomal secretion
Biological Process GO:1903553 positive regulation of extracellular exosome assembly
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0015031 protein transport
Biological Process GO:0010824 regulation of centrosome duplication
Biological Process GO:1903551 regulation of extracellular exosome assembly
Biological Process GO:0090559 regulation of membrane permeability
Biological Process GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
Biological Process GO:0046755 viral budding
Biological Process GO:0039702 viral budding via host ESCRT complex

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.