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Overview

Uniprot IDQ8WV24
Protein NamePleckstrin homology-like domain family A member 1
Gene NamePHLDA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
293 RQAILAVKSTRQKQQ

Function

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation

Protein Sequence

10 MRRAPAAERL 20 LELGFPPRCG 30 RQEPPFPLGV 40 TRGWGRWPIQ 50 KRREGARPVP 60 FSERSQEDGR 70 GPAARSSGTL 80 WRIRTRLSLC 90 RDPEPPPPLC 100 LLRVSLLCAL 110 RAGGRGSRWG 120 EDGARLLLLP 130 PARAAGNGEA 140 EPSGGPSYAG 150 RMLESSGCKA 160 LKEGVLEKRS 170 DGLLQLWKKK 180 CCILTEEGLL 190 LIPPKQLQHQ 200 QQQQQQQQQQ 210 QQQQPGQGPA 220 EPSQPSGPAV 230 ASLEPPVKLK 240 ELHFSNMKTV 250 DCVERKGKYM 260 YFTVVMAEGK 270 EIDFRCPQDQ 280 GWNAEITLQM 290 VQYKNRQAIL 300 AVKSTRQKQQ 310 HLVQQQPPSQ 320 PQPQPQLQPQ 330 PQPQPQPQPQ 340 PQSQPQPQPQ 350 PKPQPQQLHP 360 YPHPHPHPHS 370 HPHSHPHPHP 380 HPHPHQIPHP 390 HPQPHSQPHG 400 HRLLRSTSNS A

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005634 nucleus
Molecular Function GO:1901981 phosphatidylinositol phosphate binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0043065 positive regulation of apoptotic process

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.