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Overview

Uniprot IDQ8WVB6
Protein NameChromosome transmission fidelity protein 18 homolog
Gene NameCHTF18
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
336 VEPARVSKEATAPGK
343 KEATAPGKWKSHEQV

Function

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374)

Protein Sequence

10 MEDYEQELCG 20 VEDDFHNQFA 30 AELEVLAELE 40 GASTPSPSGV 50 PLFTAGRPPR 60 TFEEALARGD 70 AASSPAPAAS 80 VGSSQGGARK 90 RQVDADLQPA 100 GSLPHAPRIK 110 RPRLQVVKRL 120 NFRSEEMEEP 130 PPPDSSPTDI 140 TPPPSPEDLA 150 ELWGHGVSEA 160 AADVGLTRAS 170 PAARNPVLRR 180 PPILEDYVHV 190 TSTEGVRAYL 200 VLRADPMAPG 210 VQGSLLHVPW 220 RGGGQLDLLG 230 VSLASLKKQV 240 DGERRERLLQ 250 EAQKLSDTLH 260 SLRSGEEEAA 270 QPLGAPEEEP 280 TDGQDASSHC 290 LWVDEFAPRH 300 YTELLSDDFT 310 NRCLLKWLKL 320 WDLVVFGHER 330 PSRKPRPSVE 340 PARVSKEATA 350 PGKWKSHEQV 360 LEEMLEAGLD 370 PSQRPKQKVA 380 LLCGPPGLGK 390 TTLAHVIARH 400 AGYSVVEMNA 410 SDDRSPEVFR 420 TRIEAATQME 430 SVLGAGGKPN 440 CLVIDEIDGA 450 PVAAINVLLS 460 ILNRKGPQEV 470 GPQGPAVPSG 480 GGRRRRAEGG 490 LLMRPIICIC 500 NDQFAPSLRQ 510 LKQQAFLLHF 520 PPTLPSRLVQ 530 RLQEVSLRQG 540 MRADPGVLAA 550 LCEKTDNDIR 560 ACINTLQFLY 570 SRGQRELSVR 580 DVQATRVGLK 590 DQRRGLFSVW 600 QEVFQLPRAQ 610 RRRVGQDPAL 620 PADTLLLGDG 630 DAGSLTSASQ 640 RFYRVLHAAA 650 SAGEHEKVVQ 660 GLFDNFLRLR 670 LRDSSLGAVC 680 VALDWLAFDD 690 LLAGAAHHSQ 700 SFQLLRYPPF 710 LPVAFHVLFA 720 SSHTPRITFP 730 SSQQEAQNRM 740 SQMRNLIQTL 750 VSGIAPATRS 760 RATPQALLLD 770 ALCLLLDILA 780 PKLRPVSTQL 790 YSTREKQQLA 800 SLVGTMLAYS 810 LTYRQERTPD 820 GQYIYRLEPN 830 VEELCRFPEL 840 PARKPLTYQT 850 KQLIAREIEV 860 EKMRRAEASA 870 RVENSPQVDG 880 SPPGLEGLLG 890 GIGEKGVHRP 900 APRNHEQRLE 910 HIMRRAAREE 920 QPEKDFFGRV 930 VVRSTAVPSA 940 GDTAPEQDSV 950 ERRMGTAVGR 960 SEVWFRFNEG 970 VSNAVRRSLY IRDLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031390 Ctf18 RFC-like complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003677 DNA binding
Biological Process GO:0006260 DNA replication
Biological Process GO:1900264 positive regulation of DNA-directed DNA polymerase activity

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.