Overview
| Uniprot ID | Q8WVM7 |
|---|
| Protein Name | Cohesin subunit SA-1 |
|---|
| Gene Name | STAG1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1071 |
NSGSSSSKTSSVRNK |
| 1177 |
RTGMNYMKVRTGVRH |
Function
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis
Protein Sequence
10
MITSELPVLQ
20
DSTNETTAHS
30
DAGSELEETE
40
VKGKRKRGRP
50
GRPPSTNKKP
60
RKSPGEKSRI
70
EAGIRGAGRG
80
RANGHPQQNG
90
EGEPVTLFEV
100
VKLGKSAMQS
110
VVDDWIESYK
120
QDRDIALLDL
130
INFFIQCSGC
140
RGTVRIEMFR
150
NMQNAEIIRK
160
MTEEFDEDSG
170
DYPLTMPGPQ
180
WKKFRSNFCE
190
FIGVLIRQCQ
200
YSIIYDEYMM
210
DTVISLLTGL
220
SDSQVRAFRH
230
TSTLAAMKLM
240
TALVNVALNL
250
SIHQDNTQRQ
260
YEAERNKMIG
270
KRANERLELL
280
LQKRKELQEN
290
QDEIENMMNS
300
IFKGIFVHRY
310
RDAIAEIRAI
320
CIEEIGVWMK
330
MYSDAFLNDS
340
YLKYVGWTLH
350
DRQGEVRLKC
360
LKALQSLYTN
370
RELFPKLELF
380
TNRFKDRIVS
390
MTLDKEYDVA
400
VEAIRLVTLI
410
LHGSEEALSN
420
EDCENVYHLV
430
YSAHRPVAVA
440
AGEFLHKKLF
450
SRHDPQAEEA
460
LAKRRGRNSP
470
NGNLIRMLVL
480
FFLESELHEH
490
AAYLVDSLWE
500
SSQELLKDWE
510
CMTELLLEEP
520
VQGEEAMSDR
530
QESALIELMV
540
CTIRQAAEAH
550
PPVGRGTGKR
560
VLTAKERKTQ
570
IDDRNKLTEH
580
FIITLPMLLS
590
KYSADAEKVA
600
NLLQIPQYFD
610
LEIYSTGRME
620
KHLDALLKQI
630
KFVVEKHVES
640
DVLEACSKTY
650
SILCSEEYTI
660
QNRVDIARSQ
670
LIDEFVDRFN
680
HSVEDLLQEG
690
EEADDDDIYN
700
VLSTLKRLTS
710
FHNAHDLTKW
720
DLFGNCYRLL
730
KTGIEHGAMP
740
EQIVVQALQC
750
SHYSILWQLV
760
KITDGSPSKE
770
DLLVLRKTVK
780
SFLAVCQQCL
790
SNVNTPVKEQ
800
AFMLLCDLLM
810
IFSHQLMTGG
820
REGLQPLVFN
830
PDTGLQSELL
840
SFVMDHVFID
850
QDEENQSMEG
860
DEEDEANKIE
870
ALHKRRNLLA
880
AFSKLIIYDI
890
VDMHAAADIF
900
KHYMKYYNDY
910
GDIIKETLSK
920
TRQIDKIQCA
930
KTLILSLQQL
940
FNELVQEQGP
950
NLDRTSAHVS
960
GIKELARRFA
970
LTFGLDQIKT
980
REAVATLHKD
990
GIEFAFKYQN
1000
QKGQEYPPPN
1010
LAFLEVLSEF
1020
SSKLLRQDKK
1030
TVHSYLEKFL
1040
TEQMMERRED
1050
VWLPLISYRN
1060
SLVTGGEDDR
1070
MSVNSGSSSS
1080
KTSSVRNKKG
1090
RPPLHKKRVE
1100
DESLDNTWLN
1110
RTDTMIQTPG
1120
PLPAPQLTST
1130
VLRENSRPMG
1140
DQIQEPESEH
1150
GSEPDFLHNP
1160
QMQISWLGQP
1170
KLEDLNRKDR
1180
TGMNYMKVRT
1190
GVRHAVRGLM
1200
EEDAEPIFED
1210
VMMSSRSQLE
1220
DMNEEFEDTM
1230
VIDLPPSRNR
1240
RERAELRPDF
1250
FDSAAIIEDD
SGFGMPMF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0000775 |
chromosome, centromeric region |
| Cellular Component |
GO:0008278 |
cohesin complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0097431 |
mitotic spindle pole |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0034087 |
establishment of mitotic sister chromatid cohesion |
| Biological Process |
GO:0090307 |
mitotic spindle assembly |
| Biological Process |
GO:0007062 |
sister chromatid cohesion |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.