Search Results
Overview
| Uniprot ID | Q8WVT3 |
|---|---|
| Protein Name | Trafficking protein particle complex subunit 12 |
| Gene Name | TRAPPC12 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 510 | KVKTVCSKILANLEQ |
Function
Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224)
Protein Sequence
10
MEDAGGGEET
20
PAPEAPHPPQ
30
LAPPEEQGLL
40
FQEETIDLGG
50
DEFGSEENET
60
ASEGSSPLAD
70
KLNEHMMESV
80
LISDSPNSEG
90
DAGDLGRVRD
100
EAEPGGEGDP
110
GPEPAGTPSP
120
SGEADGDCAP
130
EDAAPSSGGA
140
PRQDAAREVP
150
GSEAARPEQE
160
PPVAEPVPVC
170
TIFSQRAPPA
180
SGDGFEPQMV
190
KSPSFGGASE
200
ASARTPPQVV
210
QPSPSLSTFF
220
GDTAASHSLA
230
SDFFDSFTTS
240
AFISVSNPGA
250
GSPAPASPPP
260
LAVPGTEGRP
270
EPVAMRGPQA
280
AAPPASPEPF
290
AHIQAVFAGS
300
DDPFATALSM
310
SEMDRRNDAW
320
LPGEATRGVL
330
RAVATQQRGA
340
VFVDKENLTM
350
PGLRFDNIQG
360
DAVKDLMLRF
370
LGEKAAAKRQ
380
VLNADSVEQS
390
FVGLKQLISC
400
RNWRAAVDLC
410
GRLLTAHGQG
420
YGKSGLLTSH
430
TTDSLQLWFV
440
RLALLVKLGL
450
FQNAEMEFEP
460
FGNLDQPDLY
470
YEYYPHVYPG
480
RRGSMVPFSM
490
RILHAELQQY
500
LGNPQESLDR
510
LHKVKTVCSK
520
ILANLEQGLA
530
EDGGMSSVTQ
540
EGRQASIRLW
550
RSRLGRVMYS
560
MANCLLLMKD
570
YVLAVEAYHS
580
VIKYYPEQEP
590
QLLSGIGRIS
600
LQIGDIKTAE
610
KYFQDVEKVT
620
QKLDGLQGKI
630
MVLMNSAFLH
640
LGQNNFAEAH
650
RFFTEILRMD
660
PRNAVANNNA
670
AVCLLYLGKL
680
KDSLRQLEAM
690
VQQDPRHYLH
700
ESVLFNLTTM
710
YELESSRSMQ
720
KKQALLEAVA
730
GKEGDSFNTQ
CLKLA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0030008 | TRAPP complex |
| Biological Process | GO:0048208 | COPII vesicle coating |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0007030 | Golgi organization |
| Biological Process | GO:0051310 | metaphase chromosome alignment |
| Biological Process | GO:1905342 | positive regulation of protein localization to kinetochore |
| Biological Process | GO:0090234 | regulation of kinetochore assembly |
| Biological Process | GO:0099022 | vesicle tethering |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.