Search Results
Overview
| Uniprot ID | Q8WVV9 |
|---|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein L-like |
| Gene Name | HNRNPLL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 71 | EAGGSHHKVSVSPVV |
Function
RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC
Protein Sequence
10
MSSSSSSPRE
20
TYEEDREYES
30
QAKRLKTEEG
40
EIDYSAEEGE
50
NRREATPRGG
60
GDGGGGGRSF
70
SQPEAGGSHH
80
KVSVSPVVHV
90
RGLCESVVEA
100
DLVEALEKFG
110
TICYVMMMPF
120
KRQALVEFEN
130
IDSAKECVTF
140
AADEPVYIAG
150
QQAFFNYSTS
160
KRITRPGNTD
170
DPSGGNKVLL
180
LSIQNPLYPI
190
TVDVLYTVCN
200
PVGKVQRIVI
210
FKRNGIQAMV
220
EFESVLCAQK
230
AKAALNGADI
240
YAGCCTLKIE
250
YARPTRLNVI
260
RNDNDSWDYT
270
KPYLGRRDRG
280
KGRQRQAILG
290
EHPSSFRHDG
300
YGSHGPLLPL
310
PSRYRMGSRD
320
TPELVAYPLP
330
QASSSYMHGG
340
NPSGSVVMVS
350
GLHQLKMNCS
360
RVFNLFCLYG
370
NIEKVKFMKT
380
IPGTALVEMG
390
DEYAVERAVT
400
HLNNVKLFGK
410
RLNVCVSKQH
420
SVVPSQIFEL
430
EDGTSSYKDF
440
AMSKNNRFTS
450
AGQASKNIIQ
460
PPSCVLHYYN
470
VPLCVTEETF
480
TKLCNDHEVL
490
TFIKYKVFDA
500
KPSAKTLSGL
510
LEWECKTDAV
520
EALTALNHYQ
530
IRVPNGSNPY
540
TLKLCFSTSS
HL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0033120 | positive regulation of RNA splicing |
| Biological Process | GO:0043484 | regulation of RNA splicing |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.