Search Results
Overview
| Uniprot ID | Q8WVY7 |
|---|---|
| Protein Name | Ubiquitin-like domain-containing CTD phosphatase 1 |
| Gene Name | UBLCP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 51 | KLLGLKVKGKPAEND |
Function
Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity (PubMed:21949367, PubMed:28539385). Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1 (PubMed:28539385). Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly (PubMed:28539385). Has also been reported to stimulate the proteolytic activity of the 26S proteasome (PubMed:32071216)
Protein Sequence
10
MALPIIVKWG
20
GQEYSVTTLS
30
EDDTVLDLKQ
40
FLKTLTGVLP
50
ERQKLLGLKV
60
KGKPAENDVK
70
LGALKLKPNT
80
KIMMMGTREE
90
SLEDVLGPPP
100
DNDDVVNDFD
110
IEDEVVEVEN
120
REENLLKISR
130
RVKEYKVEIL
140
NPPREGKKLL
150
VLDVDYTLFD
160
HRSCAETGVE
170
LMRPYLHEFL
180
TSAYEDYDIV
190
IWSATNMKWI
200
EAKMKELGVS
210
TNANYKITFM
220
LDSAAMITVH
230
TPRRGLIDVK
240
PLGVIWGKFS
250
EFYSKKNTIM
260
FDDIGRNFLM
270
NPQNGLKIRP
280
FMKAHLNRDK
290
DKELLKLTQY
300
LKEIAKLDDF
310
LDLNHKYWER
YLSKKQGQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:1904855 | proteasome regulatory particle binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Biological Process | GO:0032780 | negative regulation of ATP-dependent activity |
| Biological Process | GO:0090364 | regulation of proteasome assembly |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.