Search Results

Overview

Uniprot IDQ8WW12
Protein NamePEST proteolytic signal-containing nuclear protein
Gene NamePCNP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
13 AGDEKPEKSQRAGAA
133 PEAKMRMKNIGRDTP
150 AGPNSFNKGKHGFSD
152 PNSFNKGKHGFSDNQ
167 KLWERNIKSHLGNVH
32 EEAEKPVKTKTVSSS
34 AEKPVKTKTVSSSNG
5 ***MADGKAGDEKPE
64 EAADLPTKPTKISKF
67 DLPTKPTKISKFGFA
70 TKPTKISKFGFAIGS
81 AIGSQTTKKASAISI
82 IGSQTTKKASAISIK
89 KASAISIKLGSSKPK
96 KLGSSKPKETVPTLA

Function

May be involved in cell cycle regulation

Protein Sequence

10 MADGKAGDEK 20 PEKSQRAGAA 30 GGPEEEAEKP 40 VKTKTVSSSN 50 GGESSSRSAE 60 KRSAEEEAAD 70 LPTKPTKISK 80 FGFAIGSQTT 90 KKASAISIKL 100 GSSKPKETVP 110 TLAPKTLSVA 120 AAFNEDEDSE 130 PEEMPPEAKM 140 RMKNIGRDTP 150 TSAGPNSFNK 160 GKHGFSDNQK 170 LWERNIKSHL GNVHDQDN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0016567 protein ubiquitination

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[8] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[9] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[10] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[11] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[12] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.