Search Results

Overview

Uniprot IDQ8WWM7
Protein NameAtaxin-2-like protein
Gene NameATXN2L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
106 ARGQSTGKGPPQSPV
138 VGSTCDVKVKNGTTY
207 FNYATKDKFTDSAIA
348 SLASREGKYIPLPQR
529 ELARIAGKVPGLQNE
538 PGLQNEQKRFQLEEL
547 FQLEELRKFGAQFKL
573 PFPPRILKEEPKGKE
656 PVAEQVKKSTLNPNA
677 KPLLSVNKSTSTPTS
748 QGKYRGAKGSLPPQR

Function

Involved in the regulation of stress granule and P-body formation

Protein Sequence

10 MLKPQPLQQP 20 SQPQQPPPTQ 30 QAVARRPPGG 40 TSPPNGGLPG 50 PLATSAAPPG 60 PPAAASPCLG 70 PVAAAGSGLR 80 RGAEGILAPQ 90 PPPPQQHQER 100 PGAAAIGSAR 110 GQSTGKGPPQ 120 SPVFEGVYNN 130 SRMLHFLTAV 140 VGSTCDVKVK 150 NGTTYEGIFK 160 TLSSKFELAV 170 DAVHRKASEP 180 AGGPRREDIV 190 DTMVFKPSDV 200 MLVHFRNVDF 210 NYATKDKFTD 220 SAIAMNSKVN 230 GEHKEKVLQR 240 WEGGDSNSDD 250 YDLESDMSNG 260 WDPNEMFKFN 270 EENYGVKTTY 280 DSSLSSYTVP 290 LEKDNSEEFR 300 QRELRAAQLA 310 REIESSPQYR 320 LRIAMENDDG 330 RTEEEKHSAV 340 QRQGSGRESP 350 SLASREGKYI 360 PLPQRVREGP 370 RGGVRCSSSR 380 GGRPGLSSLP 390 PRGPHHLDNS 400 SPGPGSEARG 410 INGGPSRMSP 420 KAQRPLRGAK 430 TLSSPSNRPS 440 GETSVPPPPA 450 VGRMYPPRSP 460 KSAAPAPISA 470 SCPEPPIGSA 480 VPTSSASIPV 490 TSSVSDPGVG 500 SISPASPKIS 510 LAPTDVKELS 520 TKEPGRTLEP 530 QELARIAGKV 540 PGLQNEQKRF 550 QLEELRKFGA 560 QFKLQPSSSP 570 ENSLDPFPPR 580 ILKEEPKGKE 590 KEVDGLLTSE 600 PMGSPVSSKT 610 ESVSDKEDKP 620 PLAPSGGTEG 630 PEQPPPPCPS 640 QTGSPPVGLI 650 KGEDKDEGPV 660 AEQVKKSTLN 670 PNAKEFNPTK 680 PLLSVNKSTS 690 TPTSPGPRTH 700 STPSIPVLTA 710 GQSGLYSPQY 720 ISYIPQIHMG 730 PAVQAPQMYP 740 YPVSNSVPGQ 750 QGKYRGAKGS 760 LPPQRSDQHQ 770 PASAPPMMQA 780 AAAAGPPLVA 790 ATPYSSYIPY 800 NPQQFPGQPA 810 MMQPMAHYPS 820 QPVFAPMLQS 830 NPRMLTSGSH 840 PQAIVSSSTP 850 QYPSAEQPTP 860 QALYATVHQS 870 YPHHATQLHA 880 HQPQPATTPT 890 GSQPQSQHAA 900 PSPVQHQAGQ 910 APHLGSGQPQ 920 QNLYHPGALT 930 GTPPSLPPGP 940 SAQSPQSSFP 950 QPAAVYAIHH 960 QQLPHGFTNM 970 AHVTQAHVQT 980 GITAAPPPHP 990 GAPHPPQVML 1000 LHPPQSHGGP 1010 PQGAVPQSGV 1020 PALSASTPSP 1030 YPYIGHPQGE 1040 QPGQAPGFPG 1050 GADDRIREFS 1060 LAGGIWHGRA 1070 EGLQVGQDAR VLGGE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0010494 cytoplasmic stress granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0016607 nuclear speck
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0016071 mRNA metabolic process
Biological Process GO:0034063 stress granule assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.