Search Results

Overview

Uniprot IDQ8WWQ0
Protein NamePH-interacting protein
Gene NamePHIP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1470 RILKPQLKSESSTSA
1528 PSTSSAAKTFITKAN
1533 AAKTFITKANASAIP
154 ADTLFSRKLNGKYRL
1542 NASAIPGKTILENSV
1553 ENSVKHSKALNTLSS
158 FSRKLNGKYRLERLV
1590 KPVKRKMKSSVLPKA
1596 MKSSVLPKASTLSKS
1602 PKASTLSKSSAVIEQ
1636 GQPSKLVKRGPGRKP
1657 NSGEIIHKKRGRKPK
1658 SGEIIHKKRGRKPKK
1708 VKEDLLQKKNRGGRK
1724 KRKMKTQKLDADLLV
313 KINPRPAKFTERPRP
773 NKIPTVSKNHAHEHF

Function

Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization

Protein Sequence

10 MSCERKGLSE 20 LRSELYFLIA 30 RFLEDGPCQQ 40 AAQVLIREVA 50 EKELLPRRTD 60 WTGKEHPRTY 70 QNLVKYYRHL 80 APDHLLQICH 90 RLGPLLEQEI 100 PQSVPGVQTL 110 LGAGRQSLLR 120 TNKSCKHVVW 130 KGSALAALHC 140 GRPPESPVNY 150 GSPPSIADTL 160 FSRKLNGKYR 170 LERLVPTAVY 180 QHMKMHKRIL 190 GHLSSVYCVT 200 FDRTGRRIFT 210 GSDDCLVKIW 220 ATDDGRLLAT 230 LRGHAAEISD 240 MAVNYENTMI 250 AAGSCDKMIR 260 VWCLRTCAPL 270 AVLQGHSASI 280 TSLQFSPLCS 290 GSKRYLSSTG 300 ADGTICFWLW 310 DAGTLKINPR 320 PAKFTERPRP 330 GVQMICSSFS 340 AGGMFLATGS 350 TDHIIRVYFF 360 GSGQPEKISE 370 LEFHTDKVDS 380 IQFSNTSNRF 390 VSGSRDGTAR 400 IWQFKRREWK 410 SILLDMATRP 420 AGQNLQGIED 430 KITKMKVTMV 440 AWDRHDNTVI 450 TAVNNMTLKV 460 WNSYTGQLIH 470 VLMGHEDEVF 480 VLEPHPFDPR 490 VLFSAGHDGN 500 VIVWDLARGV 510 KIRSYFNMIE 520 GQGHGAVFDC 530 KCSPDGQHFA 540 CTDSHGHLLI 550 FGFGSSSKYD 560 KIADQMFFHS 570 DYRPLIRDAN 580 NFVLDEQTQQ 590 APHLMPPPFL 600 VDVDGNPHPS 610 RYQRLVPGRE 620 NCREEQLIPQ 630 MGVTSSGLNQ 640 VLSQQANQEI 650 SPLDSMIQRL 660 QQEQDLRRSG 670 EAVISNTSRL 680 SRGSISSTSE 690 VHSPPNVGLR 700 RSGQIEGVRQ 710 MHSNAPRSEI 720 ATERDLVAWS 730 RRVVVPELSA 740 GVASRQEEWR 750 TAKGEEEIKT 760 YRSEEKRKHL 770 TVPKENKIPT 780 VSKNHAHEHF 790 LDLGESKKQQ 800 TNQHNYRTRS 810 ALEETPRPSE 820 EIENGSSSSD 830 EGEVVAVSGG 840 TSEEEERAWH 850 SDGSSSDYSS 860 DYSDWTADAG 870 INLQPPKKVP 880 KNKTKKAESS 890 SDEEEESEKQ 900 KQKQIKKEKK 910 KVNEEKDGPI 920 SPKKKKPKER 930 KQKRLAVGEL 940 TENGLTLEEW 950 LPSTWITDTI 960 PRRCPFVPQM 970 GDEVYYFRQG 980 HEAYVEMARK 990 NKIYSINPKK 1000 QPWHKMELRE 1010 QELMKIVGIK 1020 YEVGLPTLCC 1030 LKLAFLDPDT 1040 GKLTGGSFTM 1050 KYHDMPDVID 1060 FLVLRQQFDD 1070 AKYRRWNIGD 1080 RFRSVIDDAW 1090 WFGTIESQEP 1100 LQLEYPDSLF 1110 QCYNVCWDNG 1120 DTEKMSPWDM 1130 ELIPNNAVFP 1140 EELGTSVPLT 1150 DGECRSLIYK 1160 PLDGEWGTNP 1170 RDEECERIVA 1180 GINQLMTLDI 1190 ASAFVAPVDL 1200 QAYPMYCTVV 1210 AYPTDLSTIK 1220 QRLENRFYRR 1230 VSSLMWEVRY 1240 IEHNTRTFNE 1250 PGSPIVKSAK 1260 FVTDLLLHFI 1270 KDQTCYNIIP 1280 LYNSMKKKVL 1290 SDSEDEEKDA 1300 DVPGTSTRKR 1310 KDHQPRRRLR 1320 NRAQSYDIQA 1330 WKKQCEELLN 1340 LIFQCEDSEP 1350 FRQPVDLLEY 1360 PDYRDIIDTP 1370 MDFATVRETL 1380 EAGNYESPME 1390 LCKDVRLIFS 1400 NSKAYTPSKR 1410 SRIYSMSLRL 1420 SAFFEEHISS 1430 VLSDYKSALR 1440 FHKRNTITKR 1450 RKKRNRSSSV 1460 SSSAASSPER 1470 KKRILKPQLK 1480 SESSTSAFST 1490 PTRSIPPRHN 1500 AAQINGKTES 1510 SSVVRTRSNR 1520 VVVDPVVTEQ 1530 PSTSSAAKTF 1540 ITKANASAIP 1550 GKTILENSVK 1560 HSKALNTLSS 1570 PGQSSFSHGT 1580 RNNSAKENME 1590 KEKPVKRKMK 1600 SSVLPKASTL 1610 SKSSAVIEQG 1620 DCKNNALVPG 1630 TIQVNGHGGQ 1640 PSKLVKRGPG 1650 RKPKVEVNTN 1660 SGEIIHKKRG 1670 RKPKKLQYAK 1680 PEDLEQNNVH 1690 PIRDEVLPSS 1700 TCNFLSETNN 1710 VKEDLLQKKN 1720 RGGRKPKRKM 1730 KTQKLDADLL 1740 VPASVKVLRR 1750 SNRKKIDDPI 1760 DEEEEFEELK 1770 GSEPHMRTRN 1780 QGRRTAFYNE 1790 DDSEEEQRQL 1800 LFEDTSLTFG 1810 TSSRGRVRKL 1820 TEKAKANLIG W

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0140566 histone reader activity
Molecular Function GO:0005158 insulin receptor binding
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
Biological Process GO:0045840 positive regulation of mitotic nuclear division
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0001932 regulation of protein phosphorylation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0031297 replication fork processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.