Search Results

Overview

Uniprot ID	Q8WWV3
Protein Name	NAD(P)H oxidoreductase RTN4IP1, mitochondrial
Gene Name	RTN4IP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
246	DASELVRKLGADDVI

Function

NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway (PubMed:37884807). Required for the O-methyltransferase activity of COQ3 (PubMed:37884807). Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro (PubMed:37884807). However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo (PubMed:37884807). May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (By similarity). Appears to be a potent inhibitor of regeneration following spinal cord injury (By similarity)

Protein Sequence

10 MEFLKTCVLR 20 RNACTAVCFW 30 RSKVVQKPSV 40 RRISTTSPRS 50 TVMPAWVIDK 60 YGKNEVLRFT 70 QNMMMPIIHY 80 PNEVIVKVHA 90 ASVNPIDVNM 100 RSGYGATALN 110 MKRDPLHVKI 120 KGEEFPLTLG 130 RDVSGVVMEC 140 GLDVKYFKPG 150 DEVWAAVPPW 160 KQGTLSEFVV 170 VSGNEVSHKP 180 KSLTHTQAAS 190 LPYVALTAWS 200 AINKVGGLND 210 KNCTGKRVLI 220 LGASGGVGTF 230 AIQVMKAWDA 240 HVTAVCSQDA 250 SELVRKLGAD 260 DVIDYKSGSV 270 EEQLKSLKPF 280 DFILDNVGGS 290 TETWAPDFLK 300 KWSGATYVTL 310 VTPFLLNMDR 320 LGIADGMLQT 330 GVTVGSKALK 340 HFWKGVHYRW 350 AFFMASGPCL 360 DDIAELVDAG 370 KIRPVIEQTF 380 PFSKVPEAFL 390 KVERGHARGK TVINVV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005741	mitochondrial outer membrane
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0018455	alcohol dehydrogenase [NAD(P)+] activity
Molecular Function	GO:0050136	NADH dehydrogenase (quinone) (non-electrogenic) activity
Molecular Function	GO:0008753	NADPH dehydrogenase (quinone) activity
Molecular Function	GO:0000166	nucleotide binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0050773	regulation of dendrite development
Biological Process	GO:0006744	ubiquinone biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.