Search Results

Overview

Uniprot IDQ8WWZ7
Protein NameCholesterol transporter ABCA5
Gene NameABCA5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
910 KPGDKPHKYKTSLLL

Function

Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity)

Protein Sequence

10 MSTAIREVGV 20 WRQTRTLLLK 30 NYLIKCRTKK 40 SSVQEILFPL 50 FFLFWLILIS 60 MMHPNKKYEE 70 VPNIELNPMD 80 KFTLSNLILG 90 YTPVTNITSS 100 IMQKVSTDHL 110 PDVIITEEYT 120 NEKEMLTSSL 130 SKPSNFVGVV 140 FKDSMSYELR 150 FFPDMIPVSS 160 IYMDSRAGCS 170 KSCEAAQYWS 180 SGFTVLQASI 190 DAAIIQLKTN 200 VSLWKELEST 210 KAVIMGETAV 220 VEIDTFPRGV 230 ILIYLVIAFS 240 PFGYFLAIHI 250 VAEKEKKIKE 260 FLKIMGLHDT 270 AFWLSWVLLY 280 TSLIFLMSLL 290 MAVIATASLL 300 FPQSSSIVIF 310 LLFFLYGLSS 320 VFFALMLTPL 330 FKKSKHVGIV 340 EFFVTVAFGF 350 IGLMIILIES 360 FPKSLVWLFS 370 PFCHCTFVIG 380 IAQVMHLEDF 390 NEGASFSNLT 400 AGPYPLIITI 410 IMLTLNSIFY 420 VLLAVYLDQV 430 IPGEFGLRRS 440 SLYFLKPSYW 450 SKSKRNYEEL 460 SEGNVNGNIS 470 FSEIIEPVSS 480 EFVGKEAIRI 490 SGIQKTYRKK 500 GENVEALRNL 510 SFDIYEGQIT 520 ALLGHSGTGK 530 STLMNILCGL 540 CPPSDGFASI 550 YGHRVSEIDE 560 MFEARKMIGI 570 CPQLDIHFDV 580 LTVEENLSIL 590 ASIKGIPANN 600 IIQEVQKVLL 610 DLDMQTIKDN 620 QAKKLSGGQK 630 RKLSLGIAVL 640 GNPKILLLDE 650 PTAGMDPCSR 660 HIVWNLLKYR 670 KANRVTVFST 680 HFMDEADILA 690 DRKAVISQGM 700 LKCVGSSMFL 710 KSKWGIGYRL 720 SMYIDKYCAT 730 ESLSSLVKQH 740 IPGATLLQQN 750 DQQLVYSLPF 760 KDMDKFSGLF 770 SALDSHSNLG 780 VISYGVSMTT 790 LEDVFLKLEV 800 EAEIDQADYS 810 VFTQQPLEEE 820 MDSKSFDEME 830 QSLLILSETK 840 AALVSTMSLW 850 KQQMYTIAKF 860 HFFTLKRESK 870 SVRSVLLLLL 880 IFFTVQIFMF 890 LVHHSFKNAV 900 VPIKLVPDLY 910 FLKPGDKPHK 920 YKTSLLLQNS 930 ADSDISDLIS 940 FFTSQNIMVT 950 MINDSDYVSV 960 APHSAALNVM 970 HSEKDYVFAA 980 VFNSTMVYSL 990 PILVNIISNY 1000 YLYHLNVTET 1010 IQIWSTPFFQ 1020 EITDIVFKIE 1030 LYFQAALLGI 1040 IVTAMPPYFA 1050 MENAENHKIK 1060 AYTQLKLSGL 1070 LPSAYWIGQA 1080 VVDIPLFFII 1090 LILMLGSLLA 1100 FHYGLYFYTV 1110 KFLAVVFCLI 1120 GYVPSVILFT 1130 YIASFTFKKI 1140 LNTKEFWSFI 1150 YSVAALACIA 1160 ITEITFFMGY 1170 TIATILHYAF 1180 CIIIPIYPLL 1190 GCLISFIKIS 1200 WKNVRKNVDT 1210 YNPWDRLSVA 1220 VISPYLQCVL 1230 WIFLLQYYEK 1240 KYGGRSIRKD 1250 PFFRNLSTKS 1260 KNRKLPEPPD 1270 NEDEDEDVKA 1280 ERLKVKELMG 1290 CQCCEEKPSI 1300 MVSNLHKEYD 1310 DKKDFLLSRK 1320 VKKVATKYIS 1330 FCVKKGEILG 1340 LLGPNGAGKS 1350 TIINILVGDI 1360 EPTSGQVFLG 1370 DYSSETSEDD 1380 DSLKCMGYCP 1390 QINPLWPDTT 1400 LQEHFEIYGA 1410 VKGMSASDMK 1420 EVISRITHAL 1430 DLKEHLQKTV 1440 KKLPAGIKRK 1450 LCFALSMLGN 1460 PQITLLDEPS 1470 TGMDPKAKQH 1480 MWRAIRTAFK 1490 NRKRAAILTT 1500 HYMEEAEAVC 1510 DRVAIMVSGQ 1520 LRCIGTVQHL 1530 KSKFGKGYFL 1540 EIKLKDWIEN 1550 LEVDRLQREI 1560 QYIFPNASRQ 1570 ESFSSILAYK 1580 IPKEDVQSLS 1590 QSFFKLEEAK 1600 HAFAIEEYSF 1610 SQATLEQVFV 1620 ELTKEQEEED 1630 NSCGTLNSTL 1640 WWERTQEDRV VF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005770 late endosome
Cellular Component GO:0031902 late endosome membrane
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0140359 ABC-type transporter activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0042626 ATPase-coupled transmembrane transporter activity
Molecular Function GO:0005319 lipid transporter activity
Biological Process GO:0033344 cholesterol efflux
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0034375 high-density lipoprotein particle remodeling
Biological Process GO:0006869 lipid transport
Biological Process GO:0010745 negative regulation of macrophage derived foam cell differentiation
Biological Process GO:1903064 positive regulation of reverse cholesterol transport
Biological Process GO:0010874 regulation of cholesterol efflux
Biological Process GO:0043691 reverse cholesterol transport

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.