Search Results
Overview
| Uniprot ID | Q8WWZ7 |
|---|---|
| Protein Name | Cholesterol transporter ABCA5 |
| Gene Name | ABCA5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 910 | KPGDKPHKYKTSLLL |
Function
Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity)
Protein Sequence
10
MSTAIREVGV
20
WRQTRTLLLK
30
NYLIKCRTKK
40
SSVQEILFPL
50
FFLFWLILIS
60
MMHPNKKYEE
70
VPNIELNPMD
80
KFTLSNLILG
90
YTPVTNITSS
100
IMQKVSTDHL
110
PDVIITEEYT
120
NEKEMLTSSL
130
SKPSNFVGVV
140
FKDSMSYELR
150
FFPDMIPVSS
160
IYMDSRAGCS
170
KSCEAAQYWS
180
SGFTVLQASI
190
DAAIIQLKTN
200
VSLWKELEST
210
KAVIMGETAV
220
VEIDTFPRGV
230
ILIYLVIAFS
240
PFGYFLAIHI
250
VAEKEKKIKE
260
FLKIMGLHDT
270
AFWLSWVLLY
280
TSLIFLMSLL
290
MAVIATASLL
300
FPQSSSIVIF
310
LLFFLYGLSS
320
VFFALMLTPL
330
FKKSKHVGIV
340
EFFVTVAFGF
350
IGLMIILIES
360
FPKSLVWLFS
370
PFCHCTFVIG
380
IAQVMHLEDF
390
NEGASFSNLT
400
AGPYPLIITI
410
IMLTLNSIFY
420
VLLAVYLDQV
430
IPGEFGLRRS
440
SLYFLKPSYW
450
SKSKRNYEEL
460
SEGNVNGNIS
470
FSEIIEPVSS
480
EFVGKEAIRI
490
SGIQKTYRKK
500
GENVEALRNL
510
SFDIYEGQIT
520
ALLGHSGTGK
530
STLMNILCGL
540
CPPSDGFASI
550
YGHRVSEIDE
560
MFEARKMIGI
570
CPQLDIHFDV
580
LTVEENLSIL
590
ASIKGIPANN
600
IIQEVQKVLL
610
DLDMQTIKDN
620
QAKKLSGGQK
630
RKLSLGIAVL
640
GNPKILLLDE
650
PTAGMDPCSR
660
HIVWNLLKYR
670
KANRVTVFST
680
HFMDEADILA
690
DRKAVISQGM
700
LKCVGSSMFL
710
KSKWGIGYRL
720
SMYIDKYCAT
730
ESLSSLVKQH
740
IPGATLLQQN
750
DQQLVYSLPF
760
KDMDKFSGLF
770
SALDSHSNLG
780
VISYGVSMTT
790
LEDVFLKLEV
800
EAEIDQADYS
810
VFTQQPLEEE
820
MDSKSFDEME
830
QSLLILSETK
840
AALVSTMSLW
850
KQQMYTIAKF
860
HFFTLKRESK
870
SVRSVLLLLL
880
IFFTVQIFMF
890
LVHHSFKNAV
900
VPIKLVPDLY
910
FLKPGDKPHK
920
YKTSLLLQNS
930
ADSDISDLIS
940
FFTSQNIMVT
950
MINDSDYVSV
960
APHSAALNVM
970
HSEKDYVFAA
980
VFNSTMVYSL
990
PILVNIISNY
1000
YLYHLNVTET
1010
IQIWSTPFFQ
1020
EITDIVFKIE
1030
LYFQAALLGI
1040
IVTAMPPYFA
1050
MENAENHKIK
1060
AYTQLKLSGL
1070
LPSAYWIGQA
1080
VVDIPLFFII
1090
LILMLGSLLA
1100
FHYGLYFYTV
1110
KFLAVVFCLI
1120
GYVPSVILFT
1130
YIASFTFKKI
1140
LNTKEFWSFI
1150
YSVAALACIA
1160
ITEITFFMGY
1170
TIATILHYAF
1180
CIIIPIYPLL
1190
GCLISFIKIS
1200
WKNVRKNVDT
1210
YNPWDRLSVA
1220
VISPYLQCVL
1230
WIFLLQYYEK
1240
KYGGRSIRKD
1250
PFFRNLSTKS
1260
KNRKLPEPPD
1270
NEDEDEDVKA
1280
ERLKVKELMG
1290
CQCCEEKPSI
1300
MVSNLHKEYD
1310
DKKDFLLSRK
1320
VKKVATKYIS
1330
FCVKKGEILG
1340
LLGPNGAGKS
1350
TIINILVGDI
1360
EPTSGQVFLG
1370
DYSSETSEDD
1380
DSLKCMGYCP
1390
QINPLWPDTT
1400
LQEHFEIYGA
1410
VKGMSASDMK
1420
EVISRITHAL
1430
DLKEHLQKTV
1440
KKLPAGIKRK
1450
LCFALSMLGN
1460
PQITLLDEPS
1470
TGMDPKAKQH
1480
MWRAIRTAFK
1490
NRKRAAILTT
1500
HYMEEAEAVC
1510
DRVAIMVSGQ
1520
LRCIGTVQHL
1530
KSKFGKGYFL
1540
EIKLKDWIEN
1550
LEVDRLQREI
1560
QYIFPNASRQ
1570
ESFSSILAYK
1580
IPKEDVQSLS
1590
QSFFKLEEAK
1600
HAFAIEEYSF
1610
SQATLEQVFV
1620
ELTKEQEEED
1630
NSCGTLNSTL
1640
WWERTQEDRV
VF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0140359 | ABC-type transporter activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0042626 | ATPase-coupled transmembrane transporter activity |
| Molecular Function | GO:0005319 | lipid transporter activity |
| Biological Process | GO:0033344 | cholesterol efflux |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0034375 | high-density lipoprotein particle remodeling |
| Biological Process | GO:0006869 | lipid transport |
| Biological Process | GO:0010745 | negative regulation of macrophage derived foam cell differentiation |
| Biological Process | GO:1903064 | positive regulation of reverse cholesterol transport |
| Biological Process | GO:0010874 | regulation of cholesterol efflux |
| Biological Process | GO:0043691 | reverse cholesterol transport |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.