Search Results

Overview

Uniprot ID	Q8WX93
Protein Name	Palladin
Gene Name	PALLD
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1337	HQQSQSTKPKKVRPS
1339	QSQSTKPKKVRPSAS
1340	SQSTKPKKVRPSASR
654	PPLLAKPKLDPLKLQ
883	VTPAGFPKKASRTAR
884	TPAGFPKKASRTARI

Function

Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci

Protein Sequence

10 MSGTSSHESF 20 YDSLSDMQEE 30 SKNTDFFPGL 40 SAFLSQEEIN 50 KSLDLARRAI 60 ADSETEDFDS 70 EKEISQIFST 80 SPASLCEHPS 90 HKETKLGEHA 100 SRRPQDNRST 110 PVQPLAEKQT 120 KSISSPVSKR 130 KPAMSPLLTR 140 PSYIRSLRKA 150 EKRGAKTPST 160 NVKPKTPHQR 170 KGGPQSQLCD 180 KAANLIEELT 190 SIFKAAKPRN 200 RSPNGESSSP 210 DSGYLSPKNQ 220 PSALLSASAS 230 QSPMEDQGEM 240 EREVKSPGAR 250 HCYQDNQDLA 260 VPHNRKSHPQ 270 PHSALHFPAA 280 PRFIQKLRSQ 290 EVAEGSRVYL 300 ECRVTGNPTP 310 RVRWFCEGKE 320 LHNTPDIQIH 330 CEGGDLHTLI 340 IAEAFEDDTG 350 RYTCLATNPS 360 GSDTTSAEVF 370 IEGASSTDSD 380 SESLAFKSRA 390 GAMPQAQKKT 400 TSVSLTIGSS 410 SPKTGVTTAV 420 IQPLSVPVQQ 430 VHSPTSYLCR 440 PDGTTTAYFP 450 PVFTKELQNT 460 AVAEGQVVVL 470 ECRVRGAPPL 480 QVQWFRQGSE 490 IQDSPDFRIL 500 QKKPRSTAEP 510 EEICTLVIAE 520 TFPEDAGIFT 530 CSARNDYGSA 540 TSTAQLVVTS 550 ANTENCSYES 560 MGESNNDHFQ 570 HFPPPPPILE 580 TSSLELASKK 590 PSEIQQVNNP 600 ELGLSRAALQ 610 MQFNAAERET 620 NGVHPSRGVN 630 GLINGKANSN 640 KSLPTPAVLL 650 SPTKEPPPLL 660 AKPKLDPLKL 670 QQLQNQIRLE 680 QEAGARQPPP 690 APRSAPPSPP 700 FPPPPAFPEL 710 AACTPPASPE 720 PMSALASRSA 730 PAMQSSGSFN 740 YARPKQFIAA 750 QNLGPASGHG 760 TPASSPSSSS 770 LPSPMSPTPR 780 QFGRAPVPPF 790 AQPFGAEPEA 800 PWGSSSPSPP 810 PPPPPVFSPT 820 AAFPVPDVFP 830 LPPPPPPLPS 840 PGQASHCSSP 850 ATRFGHSQTP 860 AAFLSALLPS 870 QPPPAAVNAL 880 GLPKGVTPAG 890 FPKKASRTAR 900 IASDEEIQGT 910 KDAVIQDLER 920 KLRFKEDLLN 930 NGQPRLTYEE 940 RMARRLLGAD 950 SATVFNIQEP 960 EEETANQEYK 970 VSSCEQRLIS 980 EIEYRLERSP 990 VDESGDEVQY 1000 GDVPVENGMA 1010 PFFEMKLKHY 1020 KIFEGMPVTF 1030 TCRVAGNPKP 1040 KIYWFKDGKQ 1050 ISPKSDHYTI 1060 QRDLDGTCSL 1070 HTTASTLDDD 1080 GNYTIMAANP 1090 QGRISCTGRL 1100 MVQAVNQRGR 1110 SPRSPSGHPH 1120 VRRPRSRSRD 1130 SGDENEPIQE 1140 RFFRPHFLQA 1150 PGDLTVQEGK 1160 LCRMDCKVSG 1170 LPTPDLSWQL 1180 DGKPVRPDSA 1190 HKMLVRENGV 1200 HSLIIEPVTS 1210 RDAGIYTCIA 1220 TNRAGQNSFS 1230 LELVVAAKEA 1240 HKPPVFIEKL 1250 QNTGVADGYP 1260 VRLECRVLGV 1270 PPPQIFWKKE 1280 NESLTHSTDR 1290 VSMHQDNHGY 1300 ICLLIQGATK 1310 EDAGWYTVSA 1320 KNEAGIVSCT 1330 ARLDVYTQWH 1340 QQSQSTKPKK 1350 VRPSASRYAA 1360 LSDQGLDIKA 1370 AFQPEANPSH 1380 LTLNTALVES EDL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005884	actin filament
Cellular Component	GO:0030424	axon
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0060076	excitatory synapse
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0002102	podosome
Cellular Component	GO:0001726	ruffle
Cellular Component	GO:0001725	stress fiber
Cellular Component	GO:0030018	Z disc
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0098632	cell-cell adhesion mediator activity
Molecular Function	GO:0051371	muscle alpha-actinin binding
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0007411	axon guidance
Biological Process	GO:0016477	cell migration
Biological Process	GO:0007010	cytoskeleton organization
Biological Process	GO:0070593	dendrite self-avoidance
Biological Process	GO:0007156	homophilic cell-cell adhesion

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.