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Overview

Uniprot ID	Q8WXA9
Protein Name	Splicing regulatory glutamine/lysine-rich protein 1
Gene Name	SREK1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
453	DGKEKLEKNSTSLKE

Function

Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity)

Protein Sequence

10 MTSLMPGAGL 20 LPIPTPNPLT 30 TLGVSLSSLG 40 AIPAAALDPN 50 IATLGEIPQP 60 PLMGNVDPSK 70 IDEIRRTVYV 80 GNLNSQTTTA 90 DQLLEFFKQV 100 GEVKFVRMAG 110 DETQPTRFAF 120 VEFADQNSVP 130 RALAFNGVMF 140 GDRPLKINHS 150 NNAIVKPPEM 160 TPQAAAKELE 170 EVMKRVREAQ 180 SFISAAIEPE 190 SGKSNERKGG 200 RSRSHTRSKS 210 RSSSKSHSRR 220 KRSQSKHRSR 230 SHNRSRSRQK 240 DRRRSKSPHK 250 KRSKSRERRK 260 SRSRSHSRDK 270 RKDTREKIKE 280 KERVKEKDRE 290 KEREREKERE 300 KEKERGKNKD 310 RDKEREKDRE 320 KDKEKDRERE 330 REKEHEKDRD 340 KEKEKEQDKE 350 KEREKDRSKE 360 IDEKRKKDKK 370 SRTPPRSYNA 380 SRRSRSSSRE 390 RRRRRSRSSS 400 RSPRTSKTIK 410 RKSSRSPSPR 420 SRNKKDKKRE 430 KERDHISERR 440 ERERSTSMRK 450 SSNDRDGKEK 460 LEKNSTSLKE 470 KEHNKEPDSS 480 VSKEVDDKDA 490 PRTEENKIQH 500 NGNCQLNEEN LSTKTEAV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005681	spliceosomal complex
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0008380	RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.