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Overview

Uniprot IDQ8WXE1
Protein NameATR-interacting protein
Gene NameATRIP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
32 GTGHPPSKRARGFSA
96 RLLDGMSKNPSGKNR

Function

Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein

Protein Sequence

10 MAGTSAPGSK 20 RRSEPPAPRP 30 GPPPGTGHPP 40 SKRARGFSAA 50 AAPDPDDPFG 60 AHGDFTADDL 70 EELDTLASQA 80 LSQCPAAARD 90 VSSDHKVHRL 100 LDGMSKNPSG 110 KNRETVPIKD 120 NFELEVLQAQ 130 YKELKEKMKV 140 MEEEVLIKNG 150 EIKILRDSLH 160 QTESVLEEQR 170 RSHFLLEQEK 180 TQALSDKEKE 190 FSKKLQSLQS 200 ELQFKDAEMN 210 ELRTKLQTSE 220 RANKLAAPSV 230 SHVSPRKNPS 240 VVIKPEACSP 250 QFGKTSFPTK 260 ESFSANMSLP 270 HPCQTESGYK 280 PLVGREDSKP 290 HSLRGDSIKQ 300 EEAQKSFVDS 310 WRQRSNTQGS 320 ILINLLLKQP 330 LIPGSSLSLC 340 HLLSSSSESP 350 AGTPLQPPGF 360 GSTLAGMSGL 370 RTTGSYDGSF 380 SLSALREAQN 390 LAFTGLNLVA 400 RNECSRDGDP 410 AEGGRRAFPL 420 CQLPGAVHFL 430 PLVQFFIGLH 440 CQALQDLAAA 450 KRSGAPGDSP 460 THSSCVSSGV 470 ETNPEDSVCI 480 LEGFSVTALS 490 ILQHLVCHSG 500 AVVSLLLSGV 510 GADSAAGEGN 520 RSLVHRLSDG 530 DMTSALRGVA 540 DDQGQHPLLK 550 MLLHLLAFSS 560 AATGHLQASV 570 LTQCLKVLVK 580 LAENTSCDFL 590 PRFQCVFQVL 600 PKCLSPETPL 610 PSVLLAVELL 620 SLLADHDQLA 630 PQLCSHSEGC 640 LLLLLYMYIT 650 SRPDRVALET 660 QWLQLEQEVV 670 WLLAKLGVQS 680 PLPPVTGSNC 690 QCNVEVVRAL 700 TVMLHRQWLT 710 VRRAGGPPRT 720 DQQRRTVRCL 730 RDTVLLLHGL 740 SQKDKLFMMH 750 CVEVLHQFDQ 760 VMPGVSMLIR 770 GLPDVTDCEE 780 AALDDLCAAE 790 TDVEDPEVEC G

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
Biological Process GO:0000077 DNA damage checkpoint signaling
Biological Process GO:0006281 DNA repair
Biological Process GO:0006139 nucleobase-containing compound metabolic process
Biological Process GO:2000779 regulation of double-strand break repair

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.