Search Results

Overview

Uniprot IDQ8WXF1
Protein NameParaspeckle component 1
Gene NamePSPC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
14 LKQVRIEKNPARLRA
143 ELDGTILKSRPLRIR
519 GNFEGPNKRRRY***
8 MMLRGNLKQVRIEKN

Function

RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728)

Protein Sequence

10 MMLRGNLKQV 20 RIEKNPARLR 30 ALESAVGESE 40 PAAAAAMALA 50 LAGEPAPPAP 60 APPEDHPDEE 70 MGFTIDIKSF 80 LKPGEKTYTQ 90 RCRLFVGNLP 100 TDITEEDFKR 110 LFERYGEPSE 120 VFINRDRGFG 130 FIRLESRTLA 140 EIAKAELDGT 150 ILKSRPLRIR 160 FATHGAALTV 170 KNLSPVVSNE 180 LLEQAFSQFG 190 PVEKAVVVVD 200 DRGRATGKGF 210 VEFAAKPPAR 220 KALERCGDGA 230 FLLTTTPRPV 240 IVEPMEQFDD 250 EDGLPEKLMQ 260 KTQQYHKERE 270 QPPRFAQPGT 280 FEFEYASRWK 290 ALDEMEKQQR 300 EQVDRNIREA 310 KEKLEAEMEA 320 ARHEHQLMLM 330 RQDLMRRQEE 340 LRRLEELRNQ 350 ELQKRKQIQL 360 RHEEEHRRRE 370 EEMIRHREQE 380 ELRRQQEGFK 390 PNYMENREQE 400 MRMGDMGPRG 410 AINMGDAFSP 420 APAGNQGPPP 430 MMGMNMNNRA 440 TIPGPPMGPG 450 PAMGPEGAAN 460 MGTPMMPDNG 470 AVHNDRFPQG 480 PPSQMGSPMG 490 SRTGSETPQA 500 PMSGVGPVSG 510 GPGGFGRGSQ 520 GGNFEGPNKR RRY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0042382 paraspeckles
Molecular Function GO:0003723 RNA binding
Biological Process GO:0002218 activation of innate immune response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045087 innate immune response
Biological Process GO:0140694 membraneless organelle assembly
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0048511 rhythmic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.