Search Results

Overview

Uniprot IDQ8WXI9
Protein NameTranscriptional repressor p66-beta
Gene NameGATAD2B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
199 QKENVVQKTPVVQNA
224 VGQQGLSKLPSRPGA
281 QGQRGPPKPGLVRTT
30 ERDDVLAKRLKMEGH
33 DVLAKRLKMEGHEAM
353 ANSQAAAKLALRKQL
44 HEAMERLKMLALLKR
454 SNQKKALKAEHTNRL
462 AEHTNRLKNAFVKAL
498 PAVSSVSKQETIMRH
50 LKMLALLKRKDLANL
52 MLALLKRKDLANLEV
593 SQSISGQK*******
66 VPHELPTKQDGSGVK
73 KQDGSGVKGYEEKLN
78 GVKGYEEKLNGNLRP
97 RTAGRPGKENINDEP

Function

Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463)

Protein Sequence

10 MDRMTEDALR 20 LNLLKRSLDP 30 ADERDDVLAK 40 RLKMEGHEAM 50 ERLKMLALLK 60 RKDLANLEVP 70 HELPTKQDGS 80 GVKGYEEKLN 90 GNLRPHGDNR 100 TAGRPGKENI 110 NDEPVDMSAR 120 RSEPERGRLT 130 PSPDIIVLSD 140 NEASSPRSSS 150 RMEERLKAAN 160 LEMFKGKGIE 170 ERQQLIKQLR 180 DELRLEEARL 190 VLLKKLRQSQ 200 LQKENVVQKT 210 PVVQNAASIV 220 QPSPAHVGQQ 230 GLSKLPSRPG 240 AQGVEPQNLR 250 TLQGHSVIRS 260 ATNTTLPHML 270 MSQRVIAPNP 280 AQLQGQRGPP 290 KPGLVRTTTP 300 NMNPAINYQP 310 QSSSSVPCQR 320 TTSSAIYMNL 330 ASHIQPGTVN 340 RVSSPLPSPS 350 AMTDAANSQA 360 AAKLALRKQL 370 EKTLLEIPPP 380 KPPAPLLHFL 390 PSAANSEFIY 400 MVGLEEVVQS 410 VIDSQGKSCA 420 SLLRVEPFVC 430 AQCRTDFTPH 440 WKQEKNGKIL 450 CEQCMTSNQK 460 KALKAEHTNR 470 LKNAFVKALQ 480 QEQEIEQRLQ 490 QQAALSPTTA 500 PAVSSVSKQE 510 TIMRHHTLRQ 520 APQPQSSLQR 530 GIPTSARSML 540 SNFAQAPQLS 550 VPGGLLGMPG 560 VNIAYLNTGI 570 GGHKGPSLAD 580 RQREYLLDMI 590 PPRSISQSIS GQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016581 NuRD complex
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0042659 regulation of cell fate specification
Biological Process GO:2000736 regulation of stem cell differentiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.