Search Results

Overview

Uniprot IDQ8WY36
Protein NameHMG box transcription factor BBX
Gene NameBBX
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
169 PTVNPRKKLWAFPSD
361 AEFEKSAKENLRDSK
525 KGSILDAKPPKKKVK
616 RKSERSCKGALYKTL
679 KFKKTKPKEDCLLGS
721 PVPRKKKKTGNVSSE
747 QKKNLFHKIVSKYKH
764 EKPNVPEKGSGDKWS
799 NTMEPVHKVKNIPSI
831 KRKARKTKITHLVRT
864 QLQRSLPKATETDCN

Function

Transcription factor that is necessary for cell cycle progression from G1 to S phase

Protein Sequence

10 MKGSNRNKDH 20 SAEGEGVGKR 30 PKRKCLQWHP 40 LLAKKLLDFS 50 EEEEEEDEEE 60 DIDKVQLLGA 70 DGLEQDVGET 80 EDDESPEQRA 90 RRPMNAFLLF 100 CKRHRSLVRQ 110 EHPRLDNRGA 120 TKILADWWAV 130 LDPKEKQKYT 140 DMAKEYKDAF 150 MKANPGYKWC 160 PTTNKPVKSP 170 TPTVNPRKKL 180 WAFPSDSSRD 190 LPSPKKAKTE 200 EMPQLNFGMA 210 DPTQMGGLSM 220 LLLAGEHALG 230 TPEVSSGTCR 240 PDVSESPELR 250 QKSPLFQFAE 260 ISSSTSHSDA 270 STKQCQTSAL 280 FQFAEISSNT 290 SQLGGAEPVK 300 RCGKSALFQL 310 AEMCLASEGM 320 KMEESKLIKA 330 KESDGGRIKE 340 LEKGKEEKEI 350 KMEKTDETRL 360 QKEAEFEKSA 370 KENLRDSKEL 380 RNFEALQIDD 390 IMAIKMEDPK 400 EIRKEELEED 410 HKCSHFPDFS 420 YSASSKIIIS 430 DVPSRKDHMC 440 HPHGIMIIED 450 PAALNKPEKL 460 KKKKKKSKMD 470 RHGNDKSTPK 480 KTCKKRQSSE 490 SDIESVIYTI 500 EAVAKGDWGI 510 EKLGDTPRKK 520 VRTSSSGKGS 530 ILDAKPPKKK 540 VKSREKKMSK 550 EKSSDTTKES 560 RPPDFISISA 570 SKNISGETPE 580 GIKAEPLTPM 590 EDALPPSLSG 600 QAKPEDSDCH 610 RKIETCGSRK 620 SERSCKGALY 630 KTLVSEGMLT 640 SLRANVDRGK 650 RSSGKGNSSD 660 HEGCWNEESW 670 TFSQSGTSGS 680 KKFKKTKPKE 690 DCLLGSAKLD 700 EEFEKKFNSL 710 PQYSPVTFDR 720 KCVPVPRKKK 730 KTGNVSSEPT 740 KTSKGPFQSQ 750 KKNLFHKIVS 760 KYKHKKEKPN 770 VPEKGSGDKW 780 SNKQLFLDAI 790 HPTEAIFSED 800 RNTMEPVHKV 810 KNIPSIFNTP 820 EPTTTQEPLV 830 GSQKRKARKT 840 KITHLVRTAD 850 GRVSPAGGTL 860 DDKPKEQLQR 870 SLPKATETDC 880 NDKCSHNTEV 890 GETRSSTPEM 900 PAVSAFFSLA 910 ALAEVAAMEN 920 VHRGQRSTPL 930 THDGQPKEMP 940 QAPVLISCAD Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.