Overview
| Uniprot ID | Q8WY91 |
|---|
| Protein Name | Peroxynitrite isomerase THAP4 |
|---|
| Gene Name | THAP4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 145 |
KPESRRLKQAALQGE |
Function
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region
Protein Sequence
10
MVICCAAVNC
20
SNRQGKGEKR
30
AVSFHRFPLK
40
DSKRLIQWLK
50
AVQRDNWTPT
60
KYSFLCSEHF
70
TKDSFSKRLE
80
DQHRLLKPTA
90
VPSIFHLTEK
100
KRGAGGHGRT
110
RRKDASKATG
120
GVRGHSSAAT
130
SRGAAGWSPS
140
SSGNPMAKPE
150
SRRLKQAALQ
160
GEATPRAAQE
170
AASQEQAQQA
180
LERTPGDGLA
190
TMVAGSQGKA
200
EASATDAGDE
210
SATSSIEGGV
220
TDKSGISMDD
230
FTPPGSGACK
240
FIGSLHSYSF
250
SSKHTRERPS
260
VPREPIDRKR
270
LKKDVEPSCS
280
GSSLGPDKGL
290
AQSPPSSSLT
300
ATPQKPSQSP
310
SAPPADVTPK
320
PATEAVQSEH
330
SDASPMSINE
340
VILSASGACK
350
LIDSLHSYCF
360
SSRQNKSQVC
370
CLREQVEKKN
380
GELKSLRQRV
390
SRSDSQVRKL
400
QEKLDELRRV
410
SVPYPSSLLS
420
PSREPPKMNP
430
VVEPLSWMLG
440
TWLSDPPGAG
450
TYPTLQPFQY
460
LEEVHISHVG
470
QPMLNFSFNS
480
FHPDTRKPMH
490
RECGFIRLKP
500
DTNKVAFVSA
510
QNTGVVEVEE
520
GEVNGQELCI
530
ASHSIARISF
540
AKEPHVEQIT
550
RKFRLNSEGK
560
LEQTVSMATT
570
TQPMTQHLHV
TYKKVTP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0020037 |
heme binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0070026 |
nitric oxide binding |
| Molecular Function |
GO:0062213 |
peroxynitrite isomerase activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0042126 |
nitrate metabolic process |
| Biological Process |
GO:0006570 |
tyrosine metabolic process |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.