Search Results
Overview
| Uniprot ID | Q8WYA6 |
|---|---|
| Protein Name | Beta-catenin-like protein 1 |
| Gene Name | CTNNBL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 395 | KSPRKIKKVGTTEKE |
Function
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies (PubMed:32484799)
Protein Sequence
10
MDVGELLSYQ
20
PNRGTKRPRD
30
DEEEEQKMRR
40
KQTGTRERGR
50
YREEEMTVVE
60
EADDDKKRLL
70
QIIDRDGEEE
80
EEEEEPLDES
90
SVKKMILTFE
100
KRSYKNQELR
110
IKFPDNPEKF
120
MESELDLNDI
130
IQEMHVVATM
140
PDLYHLLVEL
150
NAVQSLLGLL
160
GHDNTDVSIA
170
VVDLLQELTD
180
IDTLHESEEG
190
AEVLIDALVD
200
GQVVALLVQN
210
LERLDESVKE
220
EADGVHNTLA
230
IVENMAEFRP
240
EMCTEGAQQG
250
LLQWLLKRLK
260
AKMPFDANKL
270
YCSEVLAILL
280
QDNDENRELL
290
GELDGIDVLL
300
QQLSVFKRHN
310
PSTAEEQEMM
320
ENLFDSLCSC
330
LMLSSNRERF
340
LKGEGLQLMN
350
LMLREKKISR
360
SSALKVLDHA
370
MIGPEGTDNC
380
HKFVDILGLR
390
TIFPLFMKSP
400
RKIKKVGTTE
410
KEHEEHVCSI
420
LASLLRNLRG
430
QQRTRLLNKF
440
TENDSEKVDR
450
LMELHFKYLG
460
AMQVADKKIE
470
GEKHDMVRRG
480
EIIDNDTEEE
490
FYLRRLDAGL
500
FVLQHICYIM
510
AEICNANVPQ
520
IRQRVHQILN
530
MRGSSIKIVR
540
HIIKEYAENI
550
GDGRSPEFRE
560
NEQKRILGLL
ENF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000974 | Prp19 complex |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Molecular Function | GO:0019899 | enzyme binding |
| Biological Process | GO:0002250 | adaptive immune response |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0016445 | somatic diversification of immunoglobulins |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.