Search Results
Overview
| Uniprot ID | Q8WYK0 |
|---|---|
| Protein Name | Acetyl-coenzyme A thioesterase |
| Gene Name | ACOT12 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | NLMKESSKFDDLIFD |
| 462 | VSRRKPLKDGNTYTV |
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16951743). Preferentially hydrolyzes acetyl-CoA (PubMed:16951743)
Protein Sequence
10
MERPAPGEVV
20
MSQAIQPAHA
30
TARGELSAGQ
40
LLKWIDTTAC
50
LAAEKHAGVS
60
CVTASVDDIQ
70
FEETARVGQV
80
ITIKAKVTRA
90
FSTSMEISIK
100
VMVQDMLTGI
110
EKLVSVAFST
120
FVAKPVGKEK
130
IHLKPVTLLT
140
EQDHVEHNLA
150
AERRKVRLQH
160
EDTFNNLMKE
170
SSKFDDLIFD
180
EEEGAVSTRG
190
TSVQSIELVL
200
PPHANHHGNT
210
FGGQIMAWME
220
TVATISASRL
230
CWAHPFLKSV
240
DMFKFRGPST
250
VGDRLVFTAI
260
VNNTFQTCVE
270
VGVRVEAFDC
280
QEWAEGRGRH
290
INSAFLIYNA
300
ADDKENLITF
310
PRIQPISKDD
320
FRRYRGAIAR
330
KRIRLGRKYV
340
ISHKEEVPLC
350
IHWDISKQAS
360
LSDSNVEALK
370
KLAAKRGWEV
380
TSTVEKIKIY
390
TLEEHDVLSV
400
WVEKHVGSPA
410
HLAYRLLSDF
420
TKRPLWDPHF
430
VSCEVIDWVS
440
EDDQLYHITC
450
PILNDDKPKD
460
LVVLVSRRKP
470
LKDGNTYTVA
480
VKSVILPSVP
490
PSPQYIRSEI
500
ICAGFLIHAI
510
DSNSCIVSYF
520
NHMSASILPY
530
FAGNLGGWSK
540
SIEETAASCI
550
QFLENPPDDG
FVSTF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0003986 | acetyl-CoA hydrolase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Biological Process | GO:0006084 | acetyl-CoA metabolic process |
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0006631 | fatty acid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.