Search Results

Overview

Uniprot IDQ8WYP5
Protein NameProtein ELYS
Gene NameAHCTF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1002 SILDQYGKILPRVHR
1241 VEEDVHPKWIPGAAD
1259 LEVFTTPKKCAVPVE
1260 EVFTTPKKCAVPVET
1341 VFTASKPKSSSTALT
1425 EGKIFTQKSKVPVLD
1427 KIFTQKSKVPVLDEG
1712 MCPTKLVKSAFKTAQ
1845 GRESKRLKSSQLLEP
1979 RKRGRPRKINPSEDV
2092 LATASFTKSSRSSRT
2133 PRKAKAKKIEVPAQL
2237 GVKSKPRKTTEVTGT
2252 GLGRNRKKLSSYPKQ
2258 KKLSSYPKQILRRKM

Function

Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis

Protein Sequence

10 MRDLRAQVTS 20 GLLPFPEVTL 30 QALGEDEITL 40 ESVLRGKFAA 50 GKNGLACLAC 60 GPQLEVVNSI 70 TGERLSAYRF 80 SGVNEQPPVV 90 LAVKEFSWQK 100 RTGLLIGLEE 110 TEGSVLCLYD 120 LGISKVVKAV 130 VLPGRVTAIE 140 PIINHGGASA 150 STQHLHPSLR 160 WLFGVAAVVT 170 DVGQILLVDL 180 CLDDLSCNQN 190 EVEASDLEVL 200 TGIPAEVPHI 210 RESVMRQGRH 220 LCFQLVSPTG 230 TAVSTLSYIS 240 RTNQLAVGFS 250 DGYLALWNMK 260 SMKREYYIQL 270 ESGQVPVYAV 280 TFQEPENDPR 290 NCCYLWAVQS 300 TQDSEGDVLS 310 LHLLQLAFGN 320 RKCLASGQIL 330 YEGLEYCEER 340 YTLDLTGGMF 350 PLRGQTSNTK 360 LLGCQSIEKF 370 RSHGDREEGV 380 NEALSPDTSV 390 SVFTWQVNIY 400 GQGKPSVYLG 410 LFDINRWYHA 420 QMPDSLRSGE 430 YLHNCSYFAL 440 WSLESVVSRT 450 SPHGILDILV 460 HERSLNRGVP 470 PSYPPPEQFF 480 NPSTYNFDAT 490 CLLNSGVVHL 500 TCTGFQKETL 510 TFLKKSGPSL 520 NELIPDGYNR 530 CLVAGLLSPR 540 FVDVQPSSLS 550 QEEQLEAILS 560 AAIQTSSLGL 570 LTGYIRRWIT 580 EEQPNSATNL 590 RFVLEWTWNK 600 VVLTKEEFDR 610 LCVPLFDGSC 620 HFMDPQTIQS 630 IQQCYLLLSN 640 LNIVLSCFAS 650 EAREITERGL 660 IDLSNKFVVS 670 HLICQYAQVV 680 LWFSHSGLLP 690 EGIDDSVQLS 700 RLCYNYPVIQ 710 NYYTSRRQKF 720 ERLSRGKWNP 730 DCLMIDGLVS 740 QLGERIEKLW 750 KRDEGGTGKY 760 PPASLHAVLD 770 MYLLDGVTEA 780 AKHSITIYLL 790 LDIMYSFPNK 800 TDTPIESFPT 810 VFAISWGQVK 820 LIQGFWLIDH 830 NDYESGLDLL 840 FHPATAKPLS 850 WQHSKIIQAF 860 MSQGEHRQAL 870 RYIQTMKPTV 880 SSGNDVILHL 890 TVLLFNRCMV 900 EAWNFLRQHC 910 NRLNIEELLK 920 HMYEVCQEMG 930 LMEDLLKLPF 940 TDTEQECLVK 950 FLQSSASVQN 960 HEFLLVHHLQ 970 RANYVPALKL 980 NQTLKINVMN 990 DRDPRLRERS 1000 LARNSILDQY 1010 GKILPRVHRK 1020 LAIERAKPYH 1030 LSTSSVFRLV 1040 SRPKPLSAVP 1050 KQVVTGTVLT 1060 RSVFINNVLS 1070 KIGEVWASKE 1080 PINSTTPFNS 1090 SKIEEPSPIV 1100 YSLPAPELPE 1110 AFFGTPISKA 1120 SQKISRLLDL 1130 VVQPVPRPSQ 1140 CSEFIQQSSM 1150 KSPLYLVSRS 1160 LPSSSQLKGS 1170 PQAISRASEL 1180 HLLETPLVVK 1190 KAKSLAMSVT 1200 TSGFSEFTPQ 1210 SILRSTLRST 1220 PLASPSPSPG 1230 RSPQRLKETR 1240 ISFVEEDVHP 1250 KWIPGAADDS 1260 KLEVFTTPKK 1270 CAVPVETEWL 1280 KSKDRTTSFF 1290 LNSPEKEHQE 1300 MDEGSQSLEK 1310 LDVSKGNSSV 1320 SITSDETTLE 1330 YQDAPSPEDL 1340 EETVFTASKP 1350 KSSSTALTTN 1360 VTEQTEKDGD 1370 KDVFASEVTP 1380 SDLQKQMGNL 1390 EDAETKDLLV 1400 AAEAFSELNH 1410 LSPVQGTEAS 1420 LCAPSVYEGK 1430 IFTQKSKVPV 1440 LDEGLTSVET 1450 YTPAIRANDN 1460 KSMADVLGDG 1470 GNSSLTISEG 1480 PIVSERRLNQ 1490 EVALNLKEDH 1500 EVEVGVLKES 1510 VDLPEEKLPI 1520 SDSPPDTQEI 1530 HVIEQEKLEA 1540 QDSGEEARNL 1550 SFNELYPSGT 1560 LKLQYNFDTI 1570 DQQFCDLADN 1580 KDTAECDIAE 1590 VDGELFVAQS 1600 NFTLILEGEE 1610 GEVEPGDFAS 1620 SDVLPKAANT 1630 ATEEKLVCSG 1640 ENDNHGQIAN 1650 LPSAVTSDQK 1660 SQKVDTLPYV 1670 PEPIKVAIAE 1680 NLLDVIKDTR 1690 SKEITSDTME 1700 QSIHETIPLV 1710 SQNIMCPTKL 1720 VKSAFKTAQE 1730 TSTMTMNVSQ 1740 VDDVVSSKTR 1750 TRGQRIQNVN 1760 VKSAQQEASA 1770 DVATPKMPGQ 1780 SVRKKTRKAK 1790 EISEASENIY 1800 SDVRGLSQNQ 1810 QIPQNSVTPR 1820 RGRRKKEVNQ 1830 DILENTSSVE 1840 QELQITTGRE 1850 SKRLKSSQLL 1860 EPAVEETTKK 1870 EVKVSSVTKR 1880 TPRRIKRSVE 1890 NQESVEIIND 1900 LKVSTVTSPS 1910 RMIRKLRSTN 1920 LDASENTGNK 1930 QDDKSSDKQL 1940 RIKHVRRVRG 1950 REVSPSDVRE 1960 DSNLESSQLT 1970 VQAEFDMSAI 1980 PRKRGRPRKI 1990 NPSEDVGSKA 2000 VKEERSPKKK 2010 EAPSIRRRST 2020 RNTPAKSENV 2030 DVGKPALGKS 2040 ILVPNEELSM 2050 VMSSKKKLTK 2060 KTESQSQKRS 2070 LHSVSEERTD 2080 EMTHKETNEQ 2090 EERLLATASF 2100 TKSSRSSRTR 2110 SSKAILLPDL 2120 SEPNNEPLFS 2130 PASEVPRKAK 2140 AKKIEVPAQL 2150 KELVSDLSSQ 2160 FVISPPALRS 2170 RQKNTSNKNK 2180 LEDELKDDAQ 2190 SVETLGKPKA 2200 KRIRTSKTKQ 2210 ASKNTEKESA 2220 WSPPPIEIRL 2230 ISPLASPADG 2240 VKSKPRKTTE 2250 VTGTGLGRNR 2260 KKLSSYPKQI LRRKML

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Biological Process GO:0051301 cell division
Biological Process GO:0051028 mRNA transport
Biological Process GO:0051292 nuclear pore complex assembly
Biological Process GO:0006913 nucleocytoplasmic transport
Biological Process GO:0015031 protein transport
Biological Process GO:0032465 regulation of cytokinesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.