Search Results

Overview

Uniprot ID	Q8WZA9
Protein Name	Immunity-related GTPase family Q protein
Gene Name	IRGQ
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
355	NPKGESLKNAGGGGL
368	GLENALSKGREKCSA
379	KCSAGSQKAGSGEGP
388	GSGEGPGKAGSEGLQ
401	LQQVVGMKKSGGGDS

Function

Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation (PubMed:39481378). Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation (PubMed:39481378). Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response (PubMed:39481378). In contrast to other members of the family, does not show GTPase activity (PubMed:39481378)

Protein Sequence

10 MPPPQGDVTA 20 LFLGPPGLGK 30 SALIAALCDK 40 DVETLEAPEG 50 RPDSGVPSLR 60 AAGPGLFLGE 70 LSCPPAAPGP 80 WAAEANVLVL 90 VLPGPEGNGE 100 PLAPALGEAA 110 LAALARGTPL 120 LAVRNLRPGD 130 SQTAAQARDQ 140 TAALLNSAGL 150 GAADLFVLPA 160 NCGSSDGCEE 170 LERLRAALQS 180 QAEALRRLLP 190 PAQDGFEVLG 200 AAELEAVREA 210 FETGGLEAAL 220 SWVRSGLERL 230 GSARLDLAVA 240 GKADVGLVVD 250 MLLGLDPGDP 260 GAAPASVPTA 270 PTPFPAPERP 280 NVVLWTVPLG 290 HTGTATTAAA 300 ASHPTHYDAL 310 ILVTPGAPTE 320 KDWAQVQALL 330 LPDAPLVCVR 340 TDGEGEDPEC 350 LGEGKMENPK 360 GESLKNAGGG 370 GLENALSKGR 380 EKCSAGSQKA 390 GSGEGPGKAG 400 SEGLQQVVGM 410 KKSGGGDSER 420 AAALSPEDET 430 WEVLEEAPPP 440 VFPLRPGGLP 450 GLCEWLRRAL 460 PPAQAGALLL 470 ALPPASPSAA 480 RTKAAALRAG 490 AWRPALLASL 500 AAAAAPLPGL 510 GWACDVALLR 520 GQLAEWRRGL 530 GLEPTALARR 540 ERALGLASGE 550 LAARAHFPGP 560 VTRAEVEARL 570 GAWAGEGTAG 580 GAALGALSFL 590 WPAGGAAATG 600 GLGYRAAHGV 610 LLQALDEMRA 620 DAEAVLAPPE PAQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005776	autophagosome
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0005764	lysosome
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Biological Process	GO:0010508	positive regulation of autophagy
Biological Process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins
Biological Process	GO:0061753	substrate localization to autophagosome

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.