Search Results
Overview
| Uniprot ID | Q91V12 |
|---|---|
| Protein Name | Cytosolic acyl coenzyme A thioester hydrolase |
| Gene Name | Acot7 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 50 | RTRADHQKLGHCVTM |
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (Probable). Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (Probable). May play an important physiological function in brain (Probable)
Protein Sequence
10
MKLLVGTLRL
20
WEVGRQVAFS
30
SLTPGQECSG
40
LRKTFWAAMR
50
AVRTRADHQK
60
LGHCVTMGRI
70
MRPDDANVAG
80
NVHGGTILKM
90
IEEAGAIIST
100
RHCNSQNGER
110
CVAALARVER
120
TDFLSPMCIG
130
EVAHVSAEIT
140
YTSKHSVEVQ
150
VHVMSENILT
160
GTKKLTNKAT
170
LWYVPLSLKN
180
VDKVLEVPPI
190
VYLRQEQEEE
200
GRKRYEAQKL
210
ERMETKWRNG
220
DIVQPVLNPE
230
PNTVSYSQSS
240
LIHLVGPSDC
250
TLHGFVHGGV
260
TMKLMDEVAG
270
IVAARHCKTN
280
IVTASVDAIN
290
FHDKIRKGCV
300
ITISGRMTFT
310
SNKSMEIEVL
320
VDADPVVDNS
330
QKRYRAASAF
340
FTYVSLNQEG
350
KPMPVPQLVP
360
ETEDEKKRFE
370
EGKGRYLQMK
380
AKRQGHTEPQ
P
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0047617 | fatty acyl-CoA hydrolase activity |
| Molecular Function | GO:0000062 | fatty-acyl-CoA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0036042 | long-chain fatty acyl-CoA binding |
| Molecular Function | GO:0052816 | long-chain fatty acyl-CoA hydrolase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0015937 | coenzyme A biosynthetic process |
| Biological Process | GO:0009062 | fatty acid catabolic process |
| Biological Process | GO:0036116 | long-chain fatty-acyl-CoA catabolic process |
| Biological Process | GO:0051792 | medium-chain fatty acid biosynthetic process |
| Biological Process | GO:0036114 | medium-chain fatty-acyl-CoA catabolic process |
| Biological Process | GO:1900535 | palmitic acid biosynthetic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.