Search Results
Overview
| Uniprot ID | Q91VC7 |
|---|---|
| Protein Name | Protein phosphatase 1 regulatory subunit 14A |
| Gene Name | Ppp1r14a |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | LGKRVLSKLQSPSRA |
Function
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity)
Protein Sequence
10
MAAQRLGKRV
20
LSKLQSPSRA
30
RGPGGSPSGL
40
QKRHARVTVK
50
YDRRELQRRL
60
DVEKWIDGCL
70
EELYRGRESD
80
MPDEVNIDEL
90
LELDSEEERC
100
RKIQGLLEAC
110
ANPTEDFVQE
120
LLAKLRGLHK
130
QPGFPQPSPS
140
DDPSLSPRQD
RAHTAPP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0004865 | protein serine/threonine phosphatase inhibitor activity |
| Biological Process | GO:0071466 | cellular response to xenobiotic stimulus |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.