Search Results

Overview

Uniprot IDQ91VD9
Protein NameNADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Gene NameNdufs1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
450 DHLGDSPKILQDIAS
467 HSFCEVLKDAKKPMV
471 EVLKDAKKPMVVLGS
562 ITRQDLPKDCFIVYQ
709 RASQTMAKCVKAVTE
712 QTMAKCVKAVTEGAQ
84 MCLVEIEKAPKVVAA

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:27799543, PubMed:32072193, PubMed:38575788). Essential for catalysing the entry and efficient transfer of electrons within complex I (PubMed:27799543). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:27799543)

Protein Sequence

10 MLRIPIKRAL 20 IGLSNSPKGY 30 VRTTGTAASN 40 LIEVFVDGQS 50 VMVEPGTTVL 60 QACEKVGMQI 70 PRFCYHERLS 80 VAGNCRMCLV 90 EIEKAPKVVA 100 ACAMPVMKGW 110 NILTNSEKSK 120 KAREGVMEFL 130 LANHPLDCPI 140 CDQGGECDLQ 150 DQSMMFGSDR 160 SRFLEGKRAV 170 EDKNIGPLVK 180 TIMTRCIQCT 190 RCIRFASEIA 200 GVDDLGTTGR 210 GNDMQVGTYI 220 EKMFMSELSG 230 NVIDICPVGA 240 LTSKPYAFTA 250 RPWETRKTES 260 IDVMDAVGSN 270 IVVSTRTGEV 280 MRILPRMHED 290 INEEWISDKT 300 RFAYDGLKRQ 310 RLTEPMVRNE 320 KGLLTYTSWE 330 DALSRVAGML 340 QNFEGNAVAA 350 IAGGLVDAEA 360 LVALKDLLNK 370 VDSDNLCTEE 380 IFPTEGAGTD 390 LRSNYLLNTT 400 IAGVEEADVV 410 LLVGTNPRFE 420 APLFNARIRK 430 SWLHNDLKVA 440 LIGSPVDLTY 450 RYDHLGDSPK 460 ILQDIASGRH 470 SFCEVLKDAK 480 KPMVVLGSSA 490 LQRDDGAAIL 500 VAVSNMVQKI 510 RVTTGVAAEW 520 KVMNILHRIA 530 SQVAALDLGY 540 KPGVEAIRKN 550 PPKMLFLLGA 560 DGGCITRQDL 570 PKDCFIVYQG 580 HHGDVGAPMA 590 DVILPGAAYT 600 EKSATYVNTE 610 GRAQQTKVAV 620 TPPGLAREDW 630 KIIRALSEIA 640 GITLPYDTLD 650 QVRNRLEEVS 660 PNLVRYDDIE 670 ETNYFQQASE 680 LAKLVNQEVL 690 ADPLVPPQLT 700 IKDFYMTDSI 710 SRASQTMAKC 720 VKAVTEGAQA VEEPSIC

Gene Ontology

Classification GO ID Description
Molecular Function GO:0008137 NADH dehydrogenase (ubiquinone) activity
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005758 mitochondrial intermembrane space
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0045271 respiratory chain complex I
Molecular Function GO:0051537 2 iron, 2 sulfur cluster binding
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0016651 oxidoreductase activity, acting on NAD(P)H
Biological Process GO:0009060 aerobic respiration
Biological Process GO:0045333 cellular respiration
Biological Process GO:0006120 mitochondrial electron transport, NADH to ubiquinone
Biological Process GO:0032981 mitochondrial respiratory chain complex I assembly
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.