Overview
| Uniprot ID | Q91VH2 |
|---|
| Protein Name | Sorting nexin-9 |
|---|
| Gene Name | Snx9 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 207 |
SMKLPLNKFPGFAKP |
Function
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton (PubMed:23437151). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate (By similarity)
Protein Sequence
10
MATKARVMYD
20
FAAEPGNNEL
30
TVTEGEIITV
40
TNPNVGGGWL
50
EGKNNKGEQG
60
LVPTDYVEIL
70
PNDGKDPFSC
80
GNSVADQAFL
90
DSLTASTAQT
100
NSSSANSNNQ
110
VGGGNDPWTA
120
WNAPKPGNWD
130
SSDAWGSRTD
140
GTSAQRNSSA
150
NNWDTGFGHP
160
QAYQGPATGD
170
DDEWDEDWDD
180
PKSSSPYFKD
190
SEPAEAGGIQ
200
RGNSRAGASS
210
MKLPLNKFPG
220
FAKPGMEQYL
230
LAKQLAKPKE
240
KIAIIVGDYG
250
PMWVYPTSTF
260
DCVVADPRKG
270
SKMYGLKSYI
280
EYQLTPTNTN
290
RSVNHRYKHF
300
DWLYERLLVK
310
FGSAIPIPSL
320
PDKQVTGRFE
330
EEFIKMRMER
340
LQAWMTRMCR
350
HPVVSESEVF
360
QQFLNFRDEK
370
EWKTGKRKAE
380
KDELVGVMIF
390
STMEPEAPDL
400
DLIEIEQKCD
410
AVGKFTKAMD
420
DGVKELLTVG
430
QEHWKRCTGP
440
LPKEYQKIGK
450
ALQSLAAVFS
460
SSGYQGETDL
470
NDAITEAGKT
480
YEEIASLVAE
490
QPKKDLHFLM
500
ECNHEYKGFL
510
GCFPDIIGAH
520
KGAIEKVKES
530
DKLVATSKIT
540
PQDKQTMVKR
550
VGTMSYALQA
560
EMNHFHSNRI
570
YDYNSVIRLY
580
LEQQVQFYET
590
IAEKLRQALS
RFPVM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005905 |
clathrin-coated pit |
| Cellular Component |
GO:0030136 |
clathrin-coated vesicle |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0030659 |
cytoplasmic vesicle membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0001726 |
ruffle |
| Cellular Component |
GO:0005802 |
trans-Golgi network |
| Molecular Function |
GO:0005545 |
1-phosphatidylinositol binding |
| Molecular Function |
GO:0071933 |
Arp2/3 complex binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0035091 |
phosphatidylinositol binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0036089 |
cleavage furrow formation |
| Biological Process |
GO:0006897 |
endocytosis |
| Biological Process |
GO:0016197 |
endosomal transport |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0060988 |
lipid tube assembly |
| Biological Process |
GO:0000281 |
mitotic cytokinesis |
| Biological Process |
GO:0097320 |
plasma membrane tubulation |
| Biological Process |
GO:0030838 |
positive regulation of actin filament polymerization |
| Biological Process |
GO:0043547 |
positive regulation of GTPase activity |
| Biological Process |
GO:0051044 |
positive regulation of membrane protein ectodomain proteolysis |
| Biological Process |
GO:0045860 |
positive regulation of protein kinase activity |
| Biological Process |
GO:0065003 |
protein-containing complex assembly |
| Biological Process |
GO:0006898 |
receptor-mediated endocytosis |
| Biological Process |
GO:1900242 |
regulation of synaptic vesicle endocytosis |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.