Search Results
Overview
| Uniprot ID | Q91VM9 |
|---|---|
| Protein Name | Inorganic pyrophosphatase 2, mitochondrial |
| Gene Name | Ppa2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 237 | LNWFRLYKVPDGKPE |
| 242 | LYKVPDGKPENKFAF |
| 68 | IPLKADCKEEHDIPR |
Function
Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function
Protein Sequence
10
MRALLPLLSV
20
GRGWRVGAAA
30
RPPRRVMSLY
40
RTEELGHPRS
50
QDYRLFFKHV
60
AGHYISPFHD
70
IPLKADCKEE
80
HDIPRKKARN
90
DEYENLFNMV
100
VEIPRWTNAK
110
MEIATEEPLN
120
PIKQDIKNGK
130
LRYTPNIFPH
140
KGYIWNYGAL
150
PQTWEDPHLR
160
DKSTDCCGDN
170
DPIDVCEIGS
180
KVLSRGDVVH
190
VKILGTLALI
200
DQSETDWKII
210
AINVNDPEAE
220
KFHDIDDVKK
230
FKPGYLEATL
240
NWFRLYKVPD
250
GKPENKFAFN
260
GEFKNKAFAL
270
DVINSAHERW
280
KEMVMKKCDK
290
GAISCVNVHI
300
CDSPFHCTME
310
EARSLVESVP
320
TPSMNKESNV
330
EEEVWHFLRN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0004427 | inorganic diphosphate phosphatase activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Biological Process | GO:0071344 | diphosphate metabolic process |
| Biological Process | GO:0006796 | phosphate-containing compound metabolic process |
| Biological Process | GO:0051881 | regulation of mitochondrial membrane potential |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.