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Overview

Uniprot IDQ91VR2
Protein NameATP synthase F(1) complex subunit gamma, mitochondrial
Gene NameAtp5f1c
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
112 AIHSSVAKQMKNEVA
115 SSVAKQMKNEVAALT
136 MIVGVGEKIKGILYR
138 VGVGEKIKGILYRTH
154 DQFLVSFKDVGRKPP
262 TAMDNASKNASDMID
39 TRRLKSIKNIQKITK
55 MKMVAAAKYARAERE
83 LYEKADIKAPEDKKK
90 KAPEDKKKHLIIGVS

Function

Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit delta, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (By similarity)

Protein Sequence

10 MFSRASVVGL 20 SACAVQPQWI 30 QVRNMATLKD 40 ITRRLKSIKN 50 IQKITKSMKM 60 VAAAKYARAE 70 RELKPARVYG 80 TGSLALYEKA 90 DIKAPEDKKK 100 HLIIGVSSDR 110 GLCGAIHSSV 120 AKQMKNEVAA 130 LTAAGKEVMI 140 VGVGEKIKGI 150 LYRTHSDQFL 160 VSFKDVGRKP 170 PTFGDASVIA 180 LELLNSGYEF 190 DEGSIIFNQF 200 KSVISYKTEE 210 KPIFSLNTIA 220 TAETMSIYDD 230 IDADVLQNYQ 240 EYNLANLIYY 250 SLKESTTSEQ 260 SARMTAMDNA 270 SKNASDMIDK 280 LTLTFNRTRQ 290 AVITKELIEI ISGAAALD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0045259 proton-transporting ATP synthase complex
Molecular Function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
Biological Process GO:0015986 proton motive force-driven ATP synthesis
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.