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Overview

Uniprot IDQ91VT4
Protein Name3-oxoacyl-[acyl-carrier-protein] reductase
Gene NameCbr4
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
189 TDMTRHLKEEHFKKN
195 LKEEHFKKNIPLGRF

Function

Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro)

Protein Sequence

10 MDKVCAVFGG 20 SRGIGRAVAQ 30 LMAQKGYRLA 40 IVSRNLEVAK 50 VTAGELGGNH 60 LAFRCDVAKE 70 QDVQSTFQEM 80 EKHLGPVNFL 90 VNAAGINRDS 100 LLVRTKTEDM 110 ISQLHTNLLG 120 SMLTCKAAMK 130 TMIQQGGSIV 140 NVGSIIGLKG 150 NVGQSAYSAT 160 KGGLVGFSRS 170 LAKEVARKKI 180 RVNVVAPGFI 190 RTDMTRHLKE 200 EHFKKNIPLG 210 RFGETLEVAH 220 AVVFLLESPY 230 ITGHVLIVDG GLQLTV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:1990204 oxidoreductase complex
Molecular Function GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
Molecular Function GO:0003955 NAD(P)H dehydrogenase (quinone) activity
Molecular Function GO:0070402 NADPH binding
Molecular Function GO:0008753 NADPH dehydrogenase (quinone) activity
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Molecular Function GO:0048038 quinone binding
Biological Process GO:0044597 daunorubicin metabolic process
Biological Process GO:0044598 doxorubicin metabolic process
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0051290 protein heterotetramerization
Biological Process GO:0051289 protein homotetramerization

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.