Overview
| Uniprot ID | Q91WD5 |
|---|
| Protein Name | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial |
|---|
| Gene Name | Ndufs2 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 425 |
RPYRCKIKAPGFAHL |
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:26437605, PubMed:29887397, PubMed:31297047, PubMed:38575788). Essential for the catalytic activity and assembly of complex I (PubMed:26437605, PubMed:29887397, PubMed:31297047). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed:30922174). Plays an important role in carotid body sensing of hypoxia (PubMed:26437605, PubMed:29887397). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (PubMed:31297047)
Protein Sequence
10
MAALRALRCL
20
RGVGAPVLRP
30
GSGIRLPSQP
40
SRGARQWQPD
50
IEWAEQFSGA
60
VMYPSKETAH
70
WKPPPWNDVD
80
ILKEKAVTNM
90
TLNFGPQHPA
100
AHGVLRLVLE
110
LSGEMVRKCD
120
PHIGLLHRGT
130
EKLIEYKTYL
140
QALPYFDRLD
150
YVSMMCNEQA
160
YSIAVEKLLN
170
IQPPPRAQWI
180
RVLFGEITRI
190
LNHIMAVTTH
200
ALDIGAMTPF
210
FWMFEEREKM
220
FEFYERVSGA
230
RMHAAYIRPG
240
GVHQDLPLGL
250
LDDIYEFSKN
260
FSLRIDEVEE
270
MLTNNRIWRN
280
RTVDIGVVTA
290
EDALNYGFSG
300
VMLRGSGIQW
310
DLRKTQPYDV
320
YDQVEFDVPI
330
GSRGDCYDRY
340
LCRVEEMRQS
350
LRIIEQCLNK
360
MPPGEIKVDD
370
AKVSPPKRAE
380
MKTSMESLIH
390
HFKLYTEGYQ
400
VPPGATYTAI
410
EAPKGEFGVY
420
LVSDGSSRPY
430
RCKIKAPGFA
440
HLAGLDKMSK
450
GHMLADVVAI
460
IGTQDIVFGE
IDR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0045271 |
respiratory chain complex I |
| Molecular Function |
GO:0051539 |
4 iron, 4 sulfur cluster binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0051287 |
NAD binding |
| Molecular Function |
GO:0008137 |
NADH dehydrogenase (ubiquinone) activity |
| Molecular Function |
GO:0003954 |
NADH dehydrogenase activity |
| Molecular Function |
GO:0019826 |
oxygen sensor activity |
| Molecular Function |
GO:0048038 |
quinone binding |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0009060 |
aerobic respiration |
| Biological Process |
GO:0071453 |
cellular response to oxygen levels |
| Biological Process |
GO:0042063 |
gliogenesis |
| Biological Process |
GO:0042775 |
mitochondrial ATP synthesis coupled electron transport |
| Biological Process |
GO:0006120 |
mitochondrial electron transport, NADH to ubiquinone |
| Biological Process |
GO:0032981 |
mitochondrial respiratory chain complex I assembly |
| Biological Process |
GO:0061351 |
neural precursor cell proliferation |
| Biological Process |
GO:0022008 |
neurogenesis |
| Biological Process |
GO:0042776 |
proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.