Overview
| Uniprot ID | Q91Y97 |
|---|
| Protein Name | Fructose-bisphosphate aldolase B |
|---|
| Gene Name | Aldob |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 147 |
KDGVDFGKWRAVLRI |
Function
Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:25637246). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041)
Protein Sequence
10
MAHRFPALTP
20
EQKKELSEIA
30
QRIVANGKGI
40
LAADESVGTM
50
GNRLQRIKVE
60
NTEENRRQFR
70
ELLFSVDNSI
80
SQSIGGVILF
90
HETLYQKDSQ
100
GNLFRNVLKE
110
KGIVVGIKLD
120
QGGAPLAGTN
130
KETTIQGLDG
140
LSERCAQYKK
150
DGVDFGKWRA
160
VLRIADQCPS
170
SLAIQENANA
180
LARYASICQQ
190
NGLVPIVEPE
200
VLPDGDHDLE
210
HCQYVSEKVL
220
AAVYKALNDH
230
HVYLEGTLLK
240
PNMVTAGHAC
250
TKKYTPEQVA
260
MATVTALHRT
270
VPAAVPGICF
280
LSGGMSEEDA
290
TLNLNAINRC
300
PLPRPWKLSF
310
SYGRALQASA
320
LAAWGGKAAN
330
KKATQEAFMK
340
RAMANCQAAQ
350
GQYVHTGSSG
360
AAATQSLFTA
SYTY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0034451 |
centriolar satellite |
| Cellular Component |
GO:0030867 |
rough endoplasmic reticulum membrane |
| Cellular Component |
GO:0030868 |
smooth endoplasmic reticulum membrane |
| Molecular Function |
GO:0051117 |
ATPase binding |
| Molecular Function |
GO:0008092 |
cytoskeletal protein binding |
| Molecular Function |
GO:0070061 |
fructose binding |
| Molecular Function |
GO:0061609 |
fructose-1-phosphate aldolase activity |
| Molecular Function |
GO:0004332 |
fructose-bisphosphate aldolase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0060090 |
molecular adaptor activity |
| Molecular Function |
GO:0031210 |
phosphatidylcholine binding |
| Biological Process |
GO:0030388 |
fructose 1,6-bisphosphate metabolic process |
| Biological Process |
GO:0006001 |
fructose catabolic process |
| Biological Process |
GO:0061624 |
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate |
| Biological Process |
GO:0006000 |
fructose metabolic process |
| Biological Process |
GO:0006094 |
gluconeogenesis |
| Biological Process |
GO:0006096 |
glycolytic process |
| Biological Process |
GO:0061625 |
glycolytic process through fructose-1-phosphate |
| Biological Process |
GO:0061615 |
glycolytic process through fructose-6-phosphate |
| Biological Process |
GO:1905856 |
negative regulation of pentose-phosphate shunt |
| Biological Process |
GO:0043434 |
response to peptide hormone |
| Biological Process |
GO:0010043 |
response to zinc ion |
| Biological Process |
GO:0070072 |
vacuolar proton-transporting V-type ATPase complex assembly |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005815 |
microtubule organizing center |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.