Overview
| Uniprot ID | Q91YE8 |
|---|
| Protein Name | Synaptopodin-2 |
|---|
| Gene Name | Synpo2 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 950 |
TSKKKGKKPLNTLDV |
Function
Has an actin-binding and actin-bundling activity (PubMed:11673475). Can induce the formation of F-actin networks. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes. Involved in regulation of cell migration. May be a tumor suppressor (By similarity)
Protein Sequence
10
MGTGDFICIS
20
MTGGAPWGFR
30
LQGGKEEQQP
40
LQVAKIRSQS
50
KASGSGLREG
60
DEVVSINGNP
70
CADLTYPEVI
80
KLMEGITDSL
90
HLLVKRPSSG
100
TSETLDSESE
110
TTNHQHLTHE
120
GPMESTTLQI
130
QQATETQSED
140
FFLAPVQTKV
150
PLTEDQSNAW
160
GYAECPKEEQ
170
APPMLGSQEG
180
HLVEEVILRQ
190
KAEAGQPGHV
200
VELQLSLSKE
210
RHQCTSGPIV
220
TLQGNDKSTS
230
PDPDWSSQLE
240
RTVHINSIPA
250
PEKADTSLTS
260
STSSGRELRV
270
IQGRDPGGAG
280
LPQVEVILDC
290
SDRLKAEECR
300
LQTGRGCVAS
310
PVEGGRSEAP
320
PSLVSFAVSS
330
EGTEHGEDQR
340
SGKDQSRPHK
350
HRARHARLRR
360
SESLSEKQVK
370
EAKSKCKSIA
380
LLLTDAPNPN
390
SKGVLMFKKR
400
RRRARKYTLV
410
SYGTGELERE
420
EEEEEDQEAG
430
DKDEISEVAF
440
LGTSESEVDE
450
ELLSDVDDNT
460
QVVNFDWDSG
470
LVDIEKRLNR
480
GDKMEMLPDT
490
TGKGALMFAK
500
RRERMEQFTA
510
QNEEEKTGGM
520
AGGGPDALQT
530
DGLRTMTSYQ
540
RKEESVRMQS
550
SVSESSFQMG
560
RSLASVPQQN
570
GFSGVSETAG
580
AQRMFPMNRT
590
AKPFLGSMNQ
600
PAAPFSPTRS
610
VTSPISDFPA
620
PPPYSAVSPP
630
PEAFSRGVSS
640
PVAGPAQPPP
650
WPQPAPWSQP
660
AFYDSSEQIA
670
SRDERIAVPA
680
KRTGILQEAK
690
RRGTTKPMFT
700
FKETKVSPNP
710
ELLSLLQNAE
720
GKRGTGGDSG
730
PEEDYLSLGA
740
EACNFMQSSA
750
KQKTPPPVAP
760
KPAVKSPSSS
770
QPVAPVSPVW
780
SPGVAPAQRP
790
AFSTSNPPNP
800
PQVTAVSSIK
810
IAQPAAPPAR
820
PASALNLAGP
830
FKGPQAVVVS
840
HNYTPKPSAP
850
TPLVNAAPAG
860
AGGPSNELPG
870
MSGKGAQLFA
880
KRQSRMEKYV
890
VDSDTVQAHT
900
VRAQSPTPSL
910
PASWKYSSNV
920
RAPPPVAYNP
930
IHSPSYPLAA
940
IKSQPPGAQA
950
SKTSKKKGKK
960
PLNTLDVMKH
970
QPYQLNASLF
980
TFQPPDSKDG
990
LPQKSTVKVS
1000
SAPAMKQALP
1010
PRQANVGSPT
1020
NAQASSVYSV
1030
PAYTSQPNFF
1040
AAEATSPVSA
1050
SPVPVSVPTS
1060
PKQESTSTSY
1070
FVAPRPKFSA
1080
KKSGVTVQVW
KPSVVEE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015629 |
actin cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0001725 |
stress fiber |
| Cellular Component |
GO:0099023 |
vesicle tethering complex |
| Cellular Component |
GO:0030018 |
Z disc |
| Molecular Function |
GO:0071889 |
14-3-3 protein binding |
| Molecular Function |
GO:0003779 |
actin binding |
| Molecular Function |
GO:0051393 |
alpha-actinin binding |
| Molecular Function |
GO:0031005 |
filamin binding |
| Molecular Function |
GO:0051371 |
muscle alpha-actinin binding |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Biological Process |
GO:0000045 |
autophagosome assembly |
| Biological Process |
GO:0061684 |
chaperone-mediated autophagy |
| Biological Process |
GO:0032233 |
positive regulation of actin filament bundle assembly |
| Biological Process |
GO:0030335 |
positive regulation of cell migration |
| Biological Process |
GO:2000298 |
regulation of Rho-dependent protein serine/threonine kinase activity |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.