Search Results
Overview
| Uniprot ID | Q91YP0 |
|---|---|
| Protein Name | L-2-hydroxyglutarate dehydrogenase, mitochondrial |
| Gene Name | L2hgdh |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 234 | KENSSRSKDGMNYPI |
Function
Catalyzes the oxidation of L-2-hydroxyglutarate to 2-oxoglutarate (alpha-ketoglutarate)
Protein Sequence
10
MWPTLRYVGG
20
VCGLARYCVA
30
GGFLRASGPA
40
SGVPGLLCGG
50
GRRSSSTSSF
60
DIVIVGGGIV
70
GLASARTLIL
80
KHPGLSIGVV
90
EKEKDLALHQ
100
TGHNSGVIHS
110
GIYYKPESLK
120
AKLCVEGAAL
130
IYEYCNLKGI
140
PYRQCGKLIV
150
AVEQEEIPRL
160
QALYERGLQN
170
GVEGLRLIQQ
180
EDIKKKEPYC
190
RGLMAIDCPY
200
TGIVNYQQVA
210
LSFAQDFQEA
220
GGSILRDFEV
230
KGIEIAKENS
240
SRSKDGMNYP
250
IAVKNSKGKE
260
IRCRYVVTCA
270
GLYSDRISEL
280
SGCNPDPQIV
290
PFRGDYLVLK
300
PEKGYLVKGN
310
IYPVPDSRFP
320
FLGVHFTPRL
330
DGTIWLGPNA
340
VLAFKREGYR
350
PFDFDARDVM
360
EVILKSGFIN
370
LVFQHFSYGV
380
NEMYKACFLS
390
ETVKHLQKFI
400
PEITISDVLR
410
GPAGVRAQAL
420
DRDGNLVEDF
430
VFDGGTGEIA
440
DRVLHVRNAP
450
SPAATSSLAI
460
SRMIAEEAQQ
RFKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0047545 | (S)-2-hydroxyglutarate dehydrogenase activity |
| Biological Process | GO:0044281 | small molecule metabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.