Overview
| Uniprot ID | Q91YQ5 |
|---|
| Protein Name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 |
|---|
| Gene Name | Rpn1 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 539 |
AVLQSRLKTEGSDLC |
Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity
Protein Sequence
10
MESPVALLLL
20
LLLCLGALAP
30
TPGSASSEAP
40
PLVNEDVKRT
50
VDLSSHLAKV
60
TAEVVLVHPG
70
GGSTSRASSF
80
VLALEPELES
90
RLAHLGVQIK
100
GEDEEDNNLE
110
VRETKIKGKS
120
GRFFTVKLPV
130
ALDPGSKISV
140
VVETVYTHVL
150
HPYPTQITQS
160
EKQFVVFEGN
170
HYFYSPYPTK
180
TQTMRVKLAS
190
RNVESYTKLG
200
NPSRSEDVLD
210
YGPFKDIPAY
220
SQDTFKVHYE
230
NNSPFLTITS
240
MTRVIEVSHW
250
GNIAVEENVD
260
LKHTGAVLKG
270
PFSRYDYQRQ
280
PDSGISSIRS
290
FKTILPAAAQ
300
DVYYRDEIGN
310
VSTSHLLILD
320
DSVEMEIRPR
330
FPLFGGWKTH
340
YIVGYNLPSY
350
EYLYNLGDQY
360
ALKMRFVDHV
370
FDEQVIDSLT
380
VKIILPEGAK
390
NIQVDSPYDI
400
SRAPDELHYT
410
YLDTFGRPVI
420
VAYKKNLVEQ
430
HIQDIVVHYT
440
FNKVLMLQEP
450
LLVVAAFYIL
460
FFTVIIYVRL
470
DFSITKDPAA
480
EARMKVACIT
490
EQVLTLVNKR
500
LGLYRHFDET
510
VNRYKQSRDI
520
STLNSGKKSL
530
ETEHKAVTSE
540
IAVLQSRLKT
550
EGSDLCDRVS
560
EMQKLDAQVK
570
ELVLKSAVEA
580
ERLVAGKLKK
590
DTYLENEKLS
600
SGKRQELVTK
IDHILDAL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0008250 |
oligosaccharyltransferase complex |
| Cellular Component |
GO:0160226 |
oligosaccharyltransferase complex A |
| Cellular Component |
GO:0160227 |
oligosaccharyltransferase complex B |
| Cellular Component |
GO:0005791 |
rough endoplasmic reticulum |
| Biological Process |
GO:0006487 |
protein N-linked glycosylation |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.