Search Results
Overview
| Uniprot ID | Q91YT0 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
| Gene Name | Ndufv1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | LKWSFMNKPSDGRPK |
| 365 | DRSTDIVKAIARLIE |
| 401 | KVMARFVKGDARPAE |
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains FMN, which is the initial electron acceptor as well as one iron-sulfur cluster
Protein Sequence
10
MLAARHFLGG
20
LVPVRVSVRF
30
SSGTTAPKKT
40
SFGSLKDEDR
50
IFTNLYGRHD
60
WRLKGALRRG
70
DWYKTKEILL
80
KGPDWILGEM
90
KTSGLRGRGG
100
AGFPTGLKWS
110
FMNKPSDGRP
120
KYLVVNADEG
130
EPGTCKDREI
140
MRHDPHKLVE
150
GCLVGGRAMG
160
ARAAYIYIRG
170
EFYNEASNLQ
180
VAIREAYEAG
190
LIGKNACGSD
200
YDFDVFVVRG
210
AGAYICGEET
220
ALIESIEGKQ
230
GKPRLKPPFP
240
ADVGVFGCPT
250
TVANVETVAV
260
SPTICRRGGT
270
WFAGFGRERN
280
SGTKLFNISG
290
HVNHPCTVEE
300
EMSVPLKELI
310
EKHAGGVTGG
320
WDNLLAVIPG
330
GSSTPLIPKS
340
VCETVLMDFD
350
ALVQAQTGLG
360
TAAVIVMDRS
370
TDIVKAIARL
380
IEFYKHESCG
390
QCTPCREGVD
400
WMNKVMARFV
410
KGDARPAEID
420
SLWEISKQIE
430
GHTICALGDG
440
AAWPVQGLIR
450
HFRPELEDRM
460
QRFAQQHRAW
QAAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0010181 | FMN binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0042775 | mitochondrial ATP synthesis coupled electron transport |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.