Search Results
Overview
| Uniprot ID | Q91Z53 |
|---|---|
| Protein Name | Glyoxylate reductase/hydroxypyruvate reductase |
| Gene Name | Grhpr |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 66 | LSDRVDKKLLDAAGA |
Function
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate (By similarity)
Protein Sequence
10
MKPARLMKVF
20
VTGPLPAEGR
30
AALAQAADCE
40
VEQWNSDDPI
50
PRKDLEQGVV
60
GAHGLLCRLS
70
DRVDKKLLDA
80
AGANLRVIST
90
LSVGVDHLAL
100
DEIKKRGIRV
110
GYTPGVLTDA
120
TAELAVSLLL
130
TTCRRLPEAI
140
EEVKNGGWSS
150
WSPLWMCGYG
160
LSQSTVGIVG
170
LGRIGQAIAR
180
RLKPFGVQRF
190
LYTGRQPRPQ
200
EAAEFQAEFV
210
PIAQLAAESD
220
FIVVSCSLTP
230
DTMGLCSKDF
240
FQKMKNTAIF
250
INISRGDVVN
260
QEDLYQALAS
270
GQIAAAGLDV
280
TTPEPLPPSH
290
PLLTLKNCVI
300
LPHIGSATYK
310
TRNTMSLLAA
320
NNLLAGLRGE
AMPSELKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1902494 | catalytic complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0031406 | carboxylic acid binding |
| Molecular Function | GO:0030267 | glyoxylate reductase (NADPH) activity |
| Molecular Function | GO:0008465 | hydroxypyruvate reductase (NADH) activity |
| Molecular Function | GO:0120509 | hydroxypyruvate reductase (NADPH) activity |
| Molecular Function | GO:0016618 | hydroxypyruvate reductase [NAD(P)H] activity |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0050661 | NADP binding |
| Molecular Function | GO:0070402 | NADPH binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0043648 | dicarboxylic acid metabolic process |
| Biological Process | GO:0046487 | glyoxylate metabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.