Search Results

Overview

Uniprot IDQ922B1
Protein NameADP-ribose glycohydrolase MACROD1
Gene NameMacrod1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
101 KEAKSFLKGLSDKQR
106 FLKGLSDKQREEHYF
115 REEHYFCKDFIKLKK
131 PTWKETAKGLAVKVE
136 TAKGLAVKVEDPKYK
141 AVKVEDPKYKKDKQL
146 DPKYKKDKQLNEKIS
207 LQNCETGKAKITCGY
209 NCETGKAKITCGYRL
94 LSTSTDWKEAKSFLK

Function

Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity

Protein Sequence

10 MSLQSQVSGR 20 LAQLRAAGQL 30 LVSLRPWPGR 40 SAGGPRPRGS 50 ACGPLVALGE 60 HGYCAWLSAG 70 VGAWGAAGRG 80 AWVRTWAPLA 90 MAAKVDLSTS 100 TDWKEAKSFL 110 KGLSDKQREE 120 HYFCKDFIKL 130 KKIPTWKETA 140 KGLAVKVEDP 150 KYKKDKQLNE 160 KISLYRGDIT 170 KLEVDAIVNA 180 ANSSLLGGGG 190 VDGCIHRAAG 200 SLLTDECRTL 210 QNCETGKAKI 220 TCGYRLPAKY 230 VIHTVGPIAV 240 GQPTASQAAE 250 LRSCYLSSLD 260 LLLEHRLRSV 270 AFPCISTGVF 280 GYPNEEAAEV 290 VLASLREWLE 300 QHKDKVDRLI 310 ICVFLEKDEG 320 IYRERLPHYF PVA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0140293 ADP-ribosylglutamate hydrolase activity
Molecular Function GO:0019213 deacetylase activity
Molecular Function GO:0016798 hydrolase activity, acting on glycosyl bonds
Molecular Function GO:0061463 O-acetyl-ADP-ribose deacetylase activity
Biological Process GO:0006974 DNA damage response
Biological Process GO:0140291 peptidyl-glutamate ADP-deribosylation
Biological Process GO:0051725 protein de-ADP-ribosylation
Biological Process GO:0042278 purine nucleoside metabolic process

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.