Overview
| Uniprot ID | Q922U2 |
|---|
| Protein Name | Keratin, type II cytoskeletal 5 |
|---|
| Gene Name | Krt5 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 251 |
LVEDYKNKYEDEINK |
| 258 |
KYEDEINKRTTAENE |
| 398 |
RSEIDNVKKQCANLQ |
Function
Structural component of intermediate filaments in basal keratinocytes of stratified epithelia (PubMed:11408584). Together with its obligate type I partner KRT14, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to the basal layer of the epidermis (PubMed:11408584). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (PubMed:19267394)
Protein Sequence
10
MSRQSSVSFR
20
SGGSRSFSAA
30
SAITPSVSRT
40
SFSSVSRSGG
50
GGGGRISLGG
60
ACGAGGYGSR
70
SLYNVGGSKR
80
ISYSSGGGSF
90
RNQFGAGGFG
100
FGGGAGSGFG
110
FGGGAGSGFG
120
FGGGAGFGGG
130
YGGAGFPVCP
140
PGGIQEVTVN
150
QNLLTPLNLQ
160
IDPTIQRVRT
170
EEREQIKTLN
180
NKFASFIDKV
190
RFLEQQNKVL
200
DTKWALLQEQ
210
GTKTIKQNLD
220
PLFEQYINNL
230
RRQLDGVLGE
240
RGRLDSELRN
250
MQDLVEDYKN
260
KYEDEINKRT
270
TAENEFVMLK
280
KDVDAAYMNK
290
VELEARVDAL
300
MDEINFMKMF
310
FDAELSQMQT
320
HVSDTSVVLS
330
MDNNRSLDLD
340
SIIAEVKAQY
350
EDIANRSRTE
360
AESWYQTKYE
370
ELQQTAGRHG
380
DDLRNTKHEI
390
SEMNRMIQRL
400
RSEIDNVKKQ
410
CANLQNAIAE
420
AEQRGELALK
430
DARNKLTELE
440
EALQKAKQDM
450
ARLLREYQEL
460
MNTKLALDVE
470
IATYRKLLEG
480
EECRLSGEGV
490
GPVNISVVTN
500
SVSSGYGGGS
510
SIGVGSGFGG
520
GLGSGFAGGL
530
GPRFTRGGGG
540
LGLGSGLSVG
550
GSGFSAGSSQ
560
GGMSFGSGGG
570
SGSSVKFVST
580
TSSSRRSFKS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0001533 |
cornified envelope |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005882 |
intermediate filament |
| Cellular Component |
GO:0045095 |
keratin filament |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0097110 |
scaffold protein binding |
| Molecular Function |
GO:0030280 |
structural constituent of skin epidermis |
| Biological Process |
GO:0045109 |
intermediate filament organization |
| Biological Process |
GO:0045107 |
intermediate filament polymerization |
| Biological Process |
GO:0031424 |
keratinization |
| Biological Process |
GO:0030334 |
regulation of cell migration |
| Biological Process |
GO:0032880 |
regulation of protein localization |
| Biological Process |
GO:0009612 |
response to mechanical stimulus |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.