Search Results

Overview

Uniprot ID	Q924D0
Protein Name	NAD(P)H oxidoreductase RTN4IP1, mitochondrial
Gene Name	Rtn4ip1
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
111	DPLHMKTKGEEFPLT
53	WVIDKYGKNEVLRFT

Function

NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway (PubMed:37884807). Required for the O-methyltransferase activity of COQ3 (By similarity). Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro (By similarity). However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo (By similarity). May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267). Appears to be a potent inhibitor of regeneration following spinal cord injury (PubMed:12067236)

Protein Sequence

10 MGVLKTCVLR 20 RSACAAACFW 30 RRTVIPKPPF 40 RGISTTSARS 50 TVMPAWVIDK 60 YGKNEVLRFT 70 QNMMLPIIHY 80 PNEVIIKVHA 90 ASVNPIDVNM 100 RSGYGATALN 110 MKRDPLHMKT 120 KGEEFPLTLG 130 RDVSGVVMEC 140 GLDVKYFQPG 150 DEVWAAVPPW 160 KQGTLSEFVV 170 VSGNEVSHKP 180 KSLTHTQAAS 190 LPYVALTAWS 200 AINKVGGLSD 210 KNCKGKRALI 220 LGASGGVGTF 230 AIQVMKAWGA 240 HVTAVCSKDA 250 SELVRKLGAD 260 EVIDYTLGSV 270 EEQLKSLKLF 280 DFILDNVGGS 290 TETWALNFLK 300 KWSGATYVTL 310 VTPFLLNMDR 320 LGVADGMLQT 330 GVTVGTKALK 340 HLWQGVHYRW 350 AFFMASGPYL 360 DEIAELVDAG 370 KIRPVIERTF 380 PFSEVPEAFL 390 KVERGHARGK TVVNVV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005741	mitochondrial outer membrane
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0018455	alcohol dehydrogenase [NAD(P)+] activity
Molecular Function	GO:0050136	NADH dehydrogenase (quinone) (non-electrogenic) activity
Molecular Function	GO:0008753	NADPH dehydrogenase (quinone) activity
Molecular Function	GO:0000166	nucleotide binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0050773	regulation of dendrite development
Biological Process	GO:0006744	ubiquinone biosynthetic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.