Search Results

Overview

Uniprot ID	Q92522
Protein Name	Histone H1.10
Gene Name	H1-10
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
143	APAPTAHKAKKAAPG
146	PTAHKAKKAAPGAAG
207	AAKPSVPKVPKGRK*
23	GMAKKVTKAGGSAAL

Function

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:33238161). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:33238161, PubMed:40516528)

Protein Sequence

10 MSVELEEALP 20 VTTAEGMAKK 30 VTKAGGSAAL 40 SPSKKRKNSK 50 KKNQPGKYSQ 60 LVVETIRRLG 70 ERNGSSLAKI 80 YTEAKKVPWF 90 DQQNGRTYLK 100 YSIKALVQND 110 TLLQVKGTGA 120 NGSFKLNRKK 130 LEGGGERRGA 140 PAAATAPAPT 150 AHKAKKAAPG 160 AAGSRRADKK 170 PARGQKPEQR 180 SHKKGAGAKK 190 DKGGKAKKTA 200 AAGGKKVKKA 210 AKPSVPKVPK GRK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0000786	nucleosome
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0003690	double-stranded DNA binding
Molecular Function	GO:0031492	nucleosomal DNA binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0030527	structural constituent of chromatin
Biological Process	GO:0030261	chromosome condensation
Biological Process	GO:0045910	negative regulation of DNA recombination
Biological Process	GO:0006334	nucleosome assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.