Search Results

Overview

Uniprot ID	Q92543
Protein Name	Sorting nexin-19
Gene Name	SNX19
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
596	LQTRLEEKPDLRKFI

Function

Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity)

Protein Sequence

10 MKTETVPPFQ 20 ETPAGSSCHL 30 NNLLSSRKLM 40 AVGVLLGWLL 50 VIHLLVNVWL 60 LCLLSALLVV 70 LGGWLGSSLA 80 GVASGRLHLE 90 RFIPLATCPP 100 CPEAERQLER 110 EINRTIQMII 120 RDFVLSWYRS 130 VSQEPAFEEE 140 MEAAMKGLVQ 150 ELRRRMSVMD 160 SHAVAQSVLT 170 LCGCHLQSYI 180 QAKEATAGKN 190 GPVEPSHLWE 200 AYCRATAPHP 210 AVHSPSAEVT 220 YTRGVVNLLL 230 QGLVPKPHLE 240 TRTGRHVVVE 250 LITCNVILPL 260 ISRLSDPDWI 270 HLVLVGIFSK 280 ARDPAPCPAS 290 APEQPSVPTS 300 LPLIAEVEQL 310 PEGRASPVAA 320 PVFLSYSEPE 330 GSAGPSPEVE 340 EGHEAVEGDL 350 GGMCEERKVG 360 NNSSHFLQPN 370 VRGPLFLCED 380 SELESPLSEL 390 GKETIMLMTP 400 GSFLSDRIQD 410 ALCALESSQA 420 LEPKDGEASE 430 GAEAEEGPGT 440 ETETGLPVST 450 LNSCPEIHID 460 TADKEIEQGD 470 VTASVTALLE 480 GPEKTCPSRP 490 SCLEKDLTND 500 VSSLDPTLPP 510 VLLSSSPPGP 520 LSSATFSFEP 530 LSSPDGPVII 540 QNLRITGTIT 550 AREHSGTGFH 560 PYTLYTVKYE 570 TALDGENSSG 580 LQQLAYHTVN 590 RRYREFLNLQ 600 TRLEEKPDLR 610 KFIKNVKGPK 620 KLFPDLPLGN 630 MDSDRVEARK 640 SLLESFLKQL 650 CAIPEIANSE 660 EVQEFLALNT 670 DARIAFVKKP 680 FMVSRIDKMV 690 VSAIVDTLKT 700 AFPRSEPQSP 710 TEELSEAETE 720 SKPQTEGKKA 730 SKSRLRFSSS 740 KISPALSVTE 750 AQDKILYCLQ 760 EGNVESETLS 770 MSAMESFIEK 780 QTKLLEMQPT 790 KAPEKDPEQP 800 PKGRVDSCVS 810 DAAVPAQDPS 820 NSDPGTETEL 830 ADTALDLLLL 840 LLTEQWKWLC 850 TENMQKFLRL 860 IFGTLVQRWL 870 EVQVANLTSP 880 QRWVQYLLLL 890 QESIWPGGVL 900 PKFPRPVRTQ 910 EQKLAAEKQA 920 LQSLMGVLPD 930 LVVEILGVNK 940 CRLSWGLVLE 950 SLQQPLINRH 960 LIYCLGDIIL 970 EFLDLSASVE 980 ESAATTSASD 990 TPGNSKRMGV SS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0031901	early endosome membrane
Molecular Function	GO:0035091	phosphatidylinositol binding
Molecular Function	GO:0032266	phosphatidylinositol-3-phosphate binding
Biological Process	GO:0002062	chondrocyte differentiation
Biological Process	GO:1990502	dense core granule maturation
Biological Process	GO:0006887	exocytosis
Biological Process	GO:0030073	insulin secretion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.