Overview
| Uniprot ID | Q92558 |
|---|
| Protein Name | Actin-binding protein WASF1 |
|---|
| Gene Name | WASF1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 206 |
DRRREWQKLAQGPEL |
Function
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568)
Protein Sequence
10
MPLVKRNIDP
20
RHLCHTALPR
30
GIKNELECVT
40
NISLANIIRQ
50
LSSLSKYAED
60
IFGELFNEAH
70
SFSFRVNSLQ
80
ERVDRLSVSV
90
TQLDPKEEEL
100
SLQDITMRKA
110
FRSSTIQDQQ
120
LFDRKTLPIP
130
LQETYDVCEQ
140
PPPLNILTPY
150
RDDGKEGLKF
160
YTNPSYFFDL
170
WKEKMLQDTE
180
DKRKEKRKQK
190
QKNLDRPHEP
200
EKVPRAPHDR
210
RREWQKLAQG
220
PELAEDDANL
230
LHKHIEVANG
240
PASHFETRPQ
250
TYVDHMDGSY
260
SLSALPFSQM
270
SELLTRAEER
280
VLVRPHEPPP
290
PPPMHGAGDA
300
KPIPTCISSA
310
TGLIENRPQS
320
PATGRTPVFV
330
SPTPPPPPPP
340
LPSALSTSSL
350
RASMTSTPPP
360
PVPPPPPPPA
370
TALQAPAVPP
380
PPAPLQIAPG
390
VLHPAPPPIA
400
PPLVQPSPPV
410
ARAAPVCETV
420
PVHPLPQGEV
430
QGLPPPPPPP
440
PLPPPGIRPS
450
SPVTVTALAH
460
PPSGLHPTPS
470
TAPGPHVPLM
480
PPSPPSQVIP
490
ASEPKRHPST
500
LPVISDARSV
510
LLEAIRKGIQ
520
LRKVEEQREQ
530
EAKHERIEND
540
VATILSRRIA
550
VEYSDSEDDS
EFDEVDWLE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015629 |
actin cytoskeleton |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0032839 |
dendrite cytoplasm |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0098794 |
postsynapse |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0031209 |
SCAR complex |
| Molecular Function |
GO:0003779 |
actin binding |
| Molecular Function |
GO:0071933 |
Arp2/3 complex binding |
| Molecular Function |
GO:0051018 |
protein kinase A binding |
| Molecular Function |
GO:0034237 |
protein kinase A regulatory subunit binding |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0030041 |
actin filament polymerization |
| Biological Process |
GO:1990416 |
cellular response to brain-derived neurotrophic factor stimulus |
| Biological Process |
GO:0097484 |
dendrite extension |
| Biological Process |
GO:0098939 |
dendritic transport of mitochondrion |
| Biological Process |
GO:0072673 |
lamellipodium morphogenesis |
| Biological Process |
GO:0007005 |
mitochondrion organization |
| Biological Process |
GO:0098885 |
modification of postsynaptic actin cytoskeleton |
| Biological Process |
GO:2000601 |
positive regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process |
GO:0051388 |
positive regulation of neurotrophin TRK receptor signaling pathway |
| Biological Process |
GO:0065003 |
protein-containing complex assembly |
| Biological Process |
GO:0016601 |
Rac protein signal transduction |
| Biological Process |
GO:0006898 |
receptor-mediated endocytosis |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.